Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca altenifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and α-terpineol
Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca altenifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and α-terpineol
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DOI：
10.1128/aem.02334-07
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发表时间：
2008-03-01
影响因子：
4.4
通讯作者：
Riley, Thomas V.
中科院分区：
文献类型：
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作者：
Papadopoulos, Chelsea J.;Carson, Christine F.;Riley, Thomas V.
使用铜绿假单胞菌的一系列外排突变体，MexAB-OprM泵被鉴定为有助于该生物体对抗菌剂茶树（互叶白千层）油及其单萜组分松油烯-4-醇、1，8-桉叶油素和α-松油醇的耐受性。这些数据表明，铜绿假单胞菌的多药外排系统可以挤出单萜和相关醇。
Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.