The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer.
The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer.
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发表时间：
2000
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通讯作者：
K. Sugden;Diane M. Stearns
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作者：
K. Sugden;Diane M. Stearns
高价铬中间体在由人类致癌物铬酸盐Cr（VI）产生的氧化DNA损伤中所起的作用越来越受到人们的关注，以建立该金属的遗传毒性和致突变性机制。在这篇综述中，作者总结了从Cr（VI）的还原代谢中形成高价铬络合物（主要是+5氧化态）和自由基物种的实验证据。一个案件是由高价铬直接或金属介导的途径，以启动氧化DNA损伤，虽然自由基物种在这个氧化过程中的作用不能排除。
The role that high valent chromium intermediates play in the oxidative DNA damage produced by the human carcinogen chromate Cr(VI) is of increasing interest for establishing a mechanism of genotoxicity and mutagenicity for this metal. In this review, the authors summarize experimental evidence for the formation of high valent chromium complexes (primarily the +5 oxidation state) and radical species from the reductive metabolism of Cr(VI). A case is made for a direct- or metal-mediated pathway by high valent chromium to initiate oxidative DNA damage, although the role of radical species in this oxidative process cannot be ruled out.