SYNCHRONIZED REARRANGEMENT OF T-CELL GAMMA-CHAIN AND BETA-CHAIN GENES IN FETAL THYMOCYTE DEVELOPMENT
SYNCHRONIZED REARRANGEMENT OF T-CELL GAMMA-CHAIN AND BETA-CHAIN GENES IN FETAL THYMOCYTE DEVELOPMENT
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DOI：
10.1126/science.3020688
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发表时间：
1986-10-24
期刊：
影响因子：
56.9
通讯作者：
KAPPLER, J
中科院分区：
文献类型：
--
作者：
BORN, W;RATHBUN, G;KAPPLER, J
小鼠T细胞的动力学。个体发育中的基因重排被确定为了解这些基因在胎儿胸腺细胞发育中的可能作用的一种方法。其中两个基因(C.Gamma.1和C.Gamma.2)在BALB/c小鼠妊娠期的第14天到第17天迅速重排。此外，这些重排似乎与T细胞受体β重排紧密同步。在相同的细胞中链接基因链。提示γ的早期转录活性可能与其早期转录活性有关。基因，它先于β基因。链基因，可能不能反映这些基因的功能激活。尽管如此，还是有成效的，因此具有潜在的功能。基因重排先于胸腺中T细胞受体的表面表达2至3天，这与γ-射线的作用相一致。胸腺细胞发育中抗原特异性阶段之前的基因产物。
Kinetics of mouse T-cell .gamma. gene rearrangements in ontogeny were determined as an approach to understanding the possible role of these genes in the development of fetal thymocytes. Two of these genes (C.gamma.1 and C.gamma.2) rearranged rapidly during days 14 to 17 of the gestational period in BALB/c mice. Moreover, these rearrangements seemed to be tightly synchronized with rearrangements of T-cell receptor .beta. chain genes in the same cells. It is suggested that the early transcriptional activity of .gamma. genes, which precedes that of .beta. chain genes, may not reflect the functional activation of these genes. Nevertheless, productive and therefore potentially functional .gamma. gene rearrangements precede surface expression of T-cell receptors in the thymus by 2 to 3 days, which is compatible with a role for .gamma. gene products in thymocyte development prior to antigen-specific stages.