Novel bioactivities of Curcuma longa constituents
Novel bioactivities of Curcuma longa constituents
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DOI：
10.1021/np970459f
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发表时间：
1998-04-01
影响因子：
5.1
通讯作者：
Nair, MG
中科院分区：
文献类型：
--
作者：
Roth, GN;Chandra, A;Nair, MG
姜黄乙酸乙酯提取物的生物活性导向分离。根茎产生三个姜黄素类化合物，其显示拓扑异构酶I和II酶抑制活性。姜黄素III（3）是最具活性的类姜黄素，在25 μ g/mL（-1）时抑制拓扑异构酶。姜黄素I（1）和姜黄素II（2）在50 μ g/mL（-1）时抑制拓扑异构酶。从根茎中提取的挥发油可得到阿姜酮（4），它对埃及伊蚊幼虫的LD_（100）为50 μ g/mL。姜黄叶己烷提取物的生物测定定向分级分离产生labda-8（17），12-diene-15，16 dial（5），其在1 μ g mL（-1）时对白色念珠菌具有抗真菌活性，在25 μ g mL（-1）时抑制克氏念珠菌和近平滑念珠菌的生长。此外，5对A.埃及伊蚊幼虫在10 μ g mL（-1）。
Bioassay-directed fractionation of ethyl acetate extract from Curcuma longa Linn. rhizomes yielded three curcuminoids, which displayed topoisomerase I and II enzyme inhibition activity. Curcumin III (3) was the most active curcuminoid, inhibiting topoisomerase at 25 mu g mL(-1). Curcumin I (1) and curcumin II (2) inhibited the topoisomerases at 50 mu g mL(-1). Practionation of the volatile oil from the rhizomes afforded ar-turmerone (4), which displayed mosquitocidal activity with an LD100 of 50 mu g mL(-1) on Aedes aegyptii larvae. Bioassay-directed fractionation of hexane extract from the turmeric leaves yielded labda-8(17),12-diene-15,16 dial (5) with antifungal activity against Candida albicans at 1 mu g mL(-1) and inhibited the growth of Candida kruseii and Candida parapsilosis at 25 mu g mL(-1). In addition, 5 displayed 100% mosquitocidal activity on A. aegyptii larvae at 10 mu g mL(-1).