The origins of the developmental origins theory
The origins of the developmental origins theory
复制标题
DOI：
10.1111/j.1365-2796.2007.01809.x
复制
发表时间：
2007-05-01
影响因子：
11.1
通讯作者：
Barker, D. J. P.
中科院分区：
文献类型：
--
作者：
Barker, D. J. P.
目前的正统观点认为，冠心病是由西化的成年人不健康的生活方式和基因遗传共同造成的。这并没有为预防这种疾病提供可靠的基础。地理研究提供了该病起源于子宫内发育的第一个线索。研究显示，英格兰和威尔士各地新生儿死亡率的差异与过去新生儿死亡率的差异密切相关。过去，大多数新生儿死亡归因于出生体重过低。这导致了一种假设，即子宫内营养不良会永久性地改变身体的结构、功能和新陈代谢，从而导致晚年患冠心病。低出生体重与冠心病之间的联系已在世界各地对男性和女性的纵向研究中得到证实。疾病起源的发展模型提供了一个新的前进方向。
Current orthodoxy states that coronary heart disease results from the unhealthy lifestyles of westernized adults together with a contribution from genetic inheritance. This does not provide a secure basis for prevention of the disease. Geographical studies gave the first clue that the disease originates during intra-uterine development. Variations in mortality from the disease across England and Wales were shown to correlate closely with past differences in death rates among newborn babies. In the past most deaths among newborns were attributed to low birthweight. This led to the hypothesis that undernutrition in utero permanently changes the body's structure, function and metabolism in ways that lead to coronary heart disease in later life. The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward.