Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
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DOI：
10.1038/sj.mp.4000282
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发表时间：
1997-07-01
影响因子：
11
通讯作者：
Remschmidt, H
中科院分区：
文献类型：
--
作者：
Hebebrand, J;Blum, WF;Remschmidt, H
急性神经性厌食症(AN)以体重轻、闭经和特定的精神病理特征为特征，其循环瘦素水平较低。在本研究中，采用灵敏的放射免疫分析(RIA)测定了23例接受AN住院治疗的青春期女性患者的血浆瘦素水平，并将其与年龄、体重指数(BMI；体重增加导致瘦素水平急剧升高，其峰值远高于体重指数匹配的对照组。在进入最终治疗阶段并在出院后接受随访的患者，随后瘦素水平波动并最终降至或低于控制范围，转诊患者的低瘦素水平可能参与闭经的发病机制和急性疾病患者的代谢状态降低，体重增加后达到的峰值瘦素水平可能是导致这一阶段能量消耗增加的原因。
Circulating leptin concentrations are known to be low in acute anorexia nervosa (AN), which is characterized by low weight, amenorrhea and specific psychopathological features, In this study plasma leptin concentrations were determined during inpatient treatment of 23 adolescent females with AN using a sensitive radioimmunoassay (RIA) and set into relationship to leptin levels of females matched for age, body mass index (BMI; kg m(-2)) and/or percent body fat, At referral patients had leptin concentrations well below the female controls, Weight gains led to steep increases of leptin levels which peaked at values well in excess of those observed in controls matched for BMI, In patients who reached the final treatment stage and who were followed-up after discharge, levels subsequently fluctuated and finally dropped into or below the control range, The low leptin levels at referral are likely to be involved in the pathogenesis of amenorrhea and the reduced metabolic state of acutely ill patients, Peak leptin levels reached after weight gain are possibly the cause of increased energy expenditure during this stage of the disorder.