Importance of serum amyloid A (SAA) level in monitoring disease activity and response to therapy in patients with prostate cancer
Importance of serum amyloid A (SAA) level in monitoring disease activity and response to therapy in patients with prostate cancer
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DOI：
10.1007/bf00256147
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发表时间：
2004
影响因子：
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通讯作者：
J. Kaneti;Y. Winikoff;S. Zimlichman;R. Shainkin‐Kestenbaum
中科院分区：
文献类型：
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作者：
J. Kaneti;Y. Winikoff;S. Zimlichman;R. Shainkin‐Kestenbaum
测定35例不同播散期患者血清中淀粉样蛋白A （SAA）和酸性磷酸酶（AcP）水平与前列腺癌活动性的相关性。在癌症活动期检测到SAA水平增加了500倍，在缓解期下降到正常范围，相比之下AcP增加了10倍。这两个参数之间的相关性非常显著（P<0.001），但SAA在活动期的敏感性为100%，而AcP的敏感性仅为85%。虽然SAA不是任何特定疾病的特异性标志物，但由于其在恶性疾病中特有的变化模式及其高敏感性，它是评估疾病活动性的有用生化参数，可以在随访期间监测对治疗的反应。
Serum amyloid A (SAA) and acid phosphatase (AcP) levels were determined in serial serum samples of 35 patients in different stages of dissemination and correlated with activity of carcinoma of the prostate. Up to 500-fold increases in SAA level were detected during active periods of cancer with a decrease towards the normal range in remission, in comparison with a 10-fold increase of AcP. The correlation between these two parameters was highly significant (P<0.001), but while SAA shows 100% sensivity during the active stage, AcP shows only 85% sensitivity. It is suggested that althouth SAA is not a specific marker for any particular illness, due to its characteristic pattern of change in malignant diseases and its high sensitivity, it represents a useful biochemical parameter for the assessment of the activity of the disease to monitor response to therapy during follow-up.