PRODUCTION OF PROSTAGLANDINS BY THE PSEUDOPREGNANT RAT UTERUS, in vitro, AND THE EFFECT OF TAMOXIFEN WITH THE IDENTIFICATION OF 6‐KETO‐PROSTAGLANDIN F1α AS A MAJOR PRODUCT
PRODUCTION OF PROSTAGLANDINS BY THE PSEUDOPREGNANT RAT UTERUS, in vitro, AND THE EFFECT OF TAMOXIFEN WITH THE IDENTIFICATION OF 6‐KETO‐PROSTAGLANDIN F1α AS A MAJOR PRODUCT
复制标题
假妊娠大鼠子宫体外前列腺素的产生以及他莫昔芬的作用，并鉴定出 6-酮基前列腺素 F1α 是主要产物
DOI：
10.1111/j.1476-5381.1977.tb06993.x
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发表时间：
1977
影响因子：
7.3
通讯作者：
N. H. Wilson
中科院分区：
文献类型：
--
作者：
Linda Fenwick;R. Jones;B. Naylor;N. Poyser;N. H. Wilson
1 Prostaglandin production by rat uterus homogenates has been studied, in vitro, on days 2 to 13 of pseudopregnancy. 2 The highest production of prostaglandins occurred on day 5. 3 The amounts of prostaglandins F and D formed were higher than the amounts of prostaglandin E on every day studied. 4 The ratios of prostaglandins F and D to prostaglandin E produced steadily decreased up to day 6. It then increased with the highest values occurring between days 10 and 13. 5 Progesterone levels in peripheral plasma increased rapidly from days 2 to 5, remained high up to day 9, then steadily decreased between days 10 and 13. 6 The anti‐oestrogenic drug, tamoxifen administered on day 2, significantly inhibited the increase of prostaglandin production which occurred on day 5. Prostaglandin E production was inhibited more than the production of prostaglandins F and D. 7 Analysis of the uterine extracts by gas chromatography and mass spectrometry showed prostaglandin F2α, F1α (in trace amounts), E2 and D2 to be present. 8 The major product detected was 6‐keto‐prostaglandin F1α. Its identification forms an addendum to the paper. 9 Also present as a major product was 6(9)‐oxy‐11,15‐dihydroxyprosta‐7,13‐dienoic acid.
