Prevalence and severity of depression in chronic viral hepatitis in Iran.
Prevalence and severity of depression in chronic viral hepatitis in Iran.
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DOI：
10.1093/gastro/gou091
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发表时间：
2015-08
影响因子：
3.6
通讯作者：
Shahbazi F
中科院分区：
文献类型：
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作者：
Mirabdolhagh Hazaveh M;Dormohammadi Toosi T;Nasiri Toosi M;Tavakoli A;Shahbazi F
目标：本研究的目的是比较慢性B型肝炎（CH B）患者、慢性丙型肝炎（CHC）患者和健康受试者中抑郁症的患病率和严重程度。方法：2011年至2012年，253人在伊玛目霍梅尼医院参加了这项横断面研究。采用汉密尔顿量表评估抑郁症的患病率和严重程度。结果如下：CHC组抑郁发生率（35.9%）显著高于健康对照组（11.3%）和CHB组（19.8%）（P均< 0.01）。但排除非活动性HBsAg携带者后，CHB和CHC患者的抑郁患病率无显著性差异（29.3%vs.35.9%，P > 0.05）。非活动性HBsAg携带者与CHB患者（排除非活动性HBsAg携带者）的抑郁患病率差异有统计学意义（10.0%比29.3%; P < 0.05）。各组抑郁程度差异无统计学意义（P > 0.05）。结论：慢性B型肝炎和慢性丙型肝炎患者进行抑郁筛查有助于疾病管理。
Aim: The aim of this study was to compare the prevalence and severity of depression in chronic hepatitis B (CHB) patients, chronic hepatitis C (CHC) patients, and healthy participants. Methods: Two hundred and fifty-three persons participated in this cross-sectional study between 2011 and 2012 in Imam Khomeini Hospital. The prevalence and severity of depression were assessed using the Hamilton Scale. Results: There was significantly higher prevalence of depression in CHC patients (35.9%) than in healthy participants (11.3%) and CHB patients (19.8%) (both P < 0.01). However, CHB and CHC patients did not differ significantly in their depression prevalence after excluding inactive hepatitis B surface antigen (HBsAg) carriers (29.3% vs. 35.9%; P > 0.05). Inactive HBsAg carriers differed significantly from CHB patients—excluding inactive HBsAg carriers—in depression prevalence (10.0% vs. 29.3%; P < 0.05). No statistically significant difference was found in depression severity between all groups (P > 0.05). Conclusion: Depression screening in chronic hepatitis B and chronic hepatitis C patients may be beneficial in disease management.