PREVENTION OF DEEP-VEIN THROMBOSIS IN MEDICAL PATIENTS BY LOW-DOSE HEPARIN
PREVENTION OF DEEP-VEIN THROMBOSIS IN MEDICAL PATIENTS BY LOW-DOSE HEPARIN
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DOI：
10.1177/003693308102600205
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
PRENTICE, CRM
中科院分区：
文献类型：
--
作者：
BELCH, JJ;LOWE, GDO;PRENTICE, CRM
在100名心力衰竭和/或胸部感染患者中进行了一项随机试验，以确定低剂量s.c.肝素降低了腿部深静脉血栓形成（DVT）的发生率。肝素（5000 U，8小时）可显著降低125 I-纤维蛋白原扫描技术诊断的DVT发生率，从26%降至4%（P < 0.01）。在入院后12小时内开始肝素治疗，并持续至患者完全移动的。除了20%的注射部位瘀伤发生率外，肝素未引起出血问题。低剂量皮下注射预防肝素推荐用于需要卧床休息> 3天的心力衰竭或胸部感染患者。
A randomized trial was undertaken in 100 patients with heart failure and/or chest infection to determine whether low-dose s.c. heparin reduced the frequency of deep vein thrombosis (DVT) in the legs. Heparin (5000 U 8 hourly) significantly reduced the frequency of DVT, diagnosed by the 125I-fibrinogen scan technique, from 26-4% (P < 0.01). Heparin was started within 12 h of admission to hospital and continued until the patient was fully mobile. Heparin did not cause bleeding problems except for a 20% incidence of injection site bruising. Prophylaxis with low-dose s.c. heparin is recommended in patients with heart failure or chest infection who require > 3 days bed rest.