Membrane recruitment of LC3 proteins during autophagosome formation
Membrane recruitment of LC3 proteins during autophagosome formation
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自噬体形成过程中 LC3 蛋白的膜募集
DOI：
10.1111/j.1872-034x.2011.00955.x
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发表时间：
2012
期刊：
影响因子：
4.2
通讯作者：
T
中科院分区：
文献类型：
--
作者：
Morita;E.;Yoshimori;T
自噬是一种应激反应，响应饥饿、生长因子剥夺、内质网应激和病原体感染等信号而上调。该通路的缺陷是许多疾病的根本原因，包括代谢异常、传染病和癌症，这些疾病与肝脏疾病密切相关。迄今为止，已有超过 30 个人类 ATG（自噬）基因被报道可调节自噬体的形成。在这篇综述中，我们总结了目前对 ATG 蛋白在非选择性和选择性自噬中自噬体形成过程中的行为的理解。
Autophagy is a stress response that is upregulated in response to signals such as starvation, growth factor deprivation, endoplasmic reticulum stress, and pathogen infection. Defects in this pathway are the underlying cause of a number of diseases, including metabolic aberrations, infectious diseases, and cancer, which are closely related to hepatic disorders. To date, more than 30 human ATG (autophagy) genes have been reported to regulate autophagosome formation. In this review, we summarize the current understanding of how ATG proteins behave during autophagosome formation in both non‐selective and selective autophagy.