A validated 1H NMR method for the determination of the degree of deacetylation of chitosan
A validated 1H NMR method for the determination of the degree of deacetylation of chitosan
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DOI：
10.1016/s0731-7085(03)00155-9
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发表时间：
2003-08-21
影响因子：
3.4
通讯作者：
Gupta, A
中科院分区：
文献类型：
--
作者：
Lavertu, M;Xia, Z;Gupta, A
通过H-1 NMR光谱测定壳聚糖脱乙酰度（DDA）的方法已正式验证。DDA范围为48 - 100%的壳聚糖已用于验证。该方法被认为是简单，快速和更精确的比其他已知的技术，如红外或滴定%DDA测量。本文讨论了该技术的精密度、耐用性、耐用性、专属性、稳定性和准确度。(C)2003年由Elsevier B. V.出版
A method for the determination of the degree of deacetylation (DDA) of chitosan by H-1 NMR spectroscopy has been formally validated. Chitosans with DDA ranging from 48 to 100% have been used for the validation. The method is found to be simple, rapid and more precise than other known techniques like IR or titration for %DDA measurements. The precision, ruggedness, robustness, specificity, stability and accuracy of the technique are discussed in this paper. (C) 2003 Published by Elsevier B.V.