Organ-Size Regulation in Mammals
Organ-Size Regulation in Mammals
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DOI：
10.1101/cshperspect.a019240
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发表时间：
2015-09-01
影响因子：
7.2
通讯作者：
Stanger, Ben Z.
中科院分区：
文献类型：
--
作者：
Penzo-Mendez, Alfredo I.;Stanger, Ben Z.
生物体和器官大小的控制是生物学的核心问题。尽管它受到了关注，但我们对成人器官大小如何确定和维持的理解仍然不完整。早期的研究表明，自主和调节机制都驱动脊椎动物器官生长，内在和外在因素都有助于器官大小。器官大小决定因素的分子性质一直是深入研究的主题，并且已经确定了控制细胞区室大小的细胞相互作用基础的主要途径。在这项工作中，我们回顾了这些数据以及这一重要研究领域的未来研究前景。
The control of organism and organ size is a central question in biology. Despite the attention it has received, our understanding of how adult organ size is determined and maintained is still incomplete. Early work has shown that both autonomous and regulated mechanisms drive vertebrate organ growth, and both intrinsic and extrinsic cues contribute to organ size. The molecular nature of organ-size determinants has been the subject of intense study, and major pathways, which underlie cell interactions controlling cell compartment size, have been identified. In this work, we review these data as well as the future perspectives of research in this important area of study.