INVESTIGATIONS ON DURSBAN INSECTICIDE . METABOLISM OF [36CL] O,O-DIETHYL O-3,5,6-TRICHLORO-2-PYRIDYL PHOSPHOROTHIOATE IN RATS
INVESTIGATIONS ON DURSBAN INSECTICIDE . METABOLISM OF [36CL] O,O-DIETHYL O-3,5,6-TRICHLORO-2-PYRIDYL PHOSPHOROTHIOATE IN RATS
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DOI：
10.1021/jf60149a017
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发表时间：
1967-01-01
影响因子：
6.1
通讯作者：
FISCHER, FS
中科院分区：
文献类型：
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作者：
SMITH, GN;WATSON, BS;FISCHER, FS
当[36C1] O，O-二乙基0-3,5,6-三氯-2-吡啶-硫代酸盐以单剂量喂给大鼠时，放射性通过尿液（90%）和粪便（10%）迅速消除。排出的产物为[36C1] 3,5,6-三氯-2-吡啶基磷酸（75 - 80%），[36C1] 3,5,6-三氯-2-吡啶醇（15 - 20%），还有微量的O，O-二乙基O-3,5,6-三氯-2-吡啶基硫代酸盐。只有[36C1] O， O[图像]二乙基O-3,5,6-三氯-2-吡啶基硫代磷酸酯在组织中积累。它会在脂肪中积累，然后慢慢释放。
When [36C1] O,O-diethyl 0-3,5,6-trichloro-2-pyridyl-phosphorothioate is fed as a single dose to rats, the radioactivity is eliminated rapidly via the urine (90%) and feces (10%). The products excreted are [36C1] 3,5,6-trichloro-2-pyridyl phosphate (75 to 80%), [36C1] 3,5,6-trichloro-2-pyridinol (15 to 20%), with traces of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate. Only the [36C1] O, O[image]diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate accumulates in the tissues. This accumulates in the fat and is liberated slowly.