Protein phosphorylation and signal transduction
Protein phosphorylation and signal transduction
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DOI：
10.1016/s0163-7258(98)00056-4
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发表时间：
1999-05-01
影响因子：
13.5
通讯作者：
Krebs, EG
中科院分区：
文献类型：
--
作者：
Graves, JD;Krebs, EG
现在普遍认为蛋白质磷酸化-去磷酸化在基本上所有细胞功能的调节中起作用。因此，有趣的是，该过程涉及信号转导。尽管如此，蛋白质磷酸化参与信号传导的程度确实令人瞩目。几乎所有已知的信号通路最终都会影响蛋白激酶，或者在某些情况下，蛋白磷酸酶。这些酶的多样性值得注意，许多生物技术公司将其视为药物的潜在重要靶点。这些药物可能具有重要的治疗应用，并且在任何情况下，它们肯定会对研究信号转导的研究人员有用。事实上，这已经被证明是正确的。(C)1999 Elsevier Science Inc. All rights reserved.
It is now generally accepted that protein phosphorylation-dephosphorylation has a role in the regulation of essentially all cellular functions. Thus, it is of interest that this process is involved in signal transduction. Nonetheless, the extent to which protein phosphorylation participates in signaling is truly remarkable. Almost every known signaling pathway eventually impinges on a protein kinase, or in some instances, a protein phosphatase. The diversity of these enzymes is noteworthy, and it is of interest that many biotechnology companies are eyeing them as potentially important targets for drugs. Such drugs may have important therapeutic applications, and in any event, they certainly will be useful to investigators who study signal transduction. Indeed, this already has been proven to be true. (C) 1999 Elsevier Science Inc. All rights reserved.