Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function
Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function
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DOI：
10.1111/j.1365-2796.2003.01296.x
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发表时间：
2004-03-01
影响因子：
11.1
通讯作者：
Bianchi, ME
中科院分区：
文献类型：
--
作者：
Müller, S;Ronfani, L;Bianchi, ME
高迁移率族蛋白1（HMGB1）被认为是一种普遍存在的具有结构功能的核蛋白，但即使是早期的报道也描述了它在细胞核外的存在。今天，我们才刚刚开始了解HMGB1的细胞核和细胞外功能：我们知道它参与发育和分化过程，触发和调节体内许多炎症级联反应，甚至可能参与癌细胞的转移侵袭程序。鉴于这种不同的作用，重要的是要知道哪些细胞表达HMGB1，在哪里，以及多少。本综述涉及HMGB1的表达模式，并提供证据表明，远离管家，HMGB1基因受到严格调控。这可能对炎症性疾病以及癌症的治疗干预有影响。
High mobility group box protein 1 (HMGB1) has been considered as a ubiquitous nuclear protein with an architectural function, but even early reports have described its presence outside of the nucleus. Today, we have only started to understand the extranuclear and extracellular functions of HMGB1: we know that it participates in developmental and differentiation processes, triggers and modulates many of the inflammatory cascades in the body, and may even be involved in the metastatic invasion programme of cancer cells. Given such diverse roles, it is important to know which cells express HMGB1, where, and how much. The present review deals with the expression pattern of HMGB1 and provides evidence that, far from being housekeeping, the HMGB1 gene is tightly regulated. This can have implications for therapeutic intervention on inflammatory diseases as well as cancer.