Utility and Limitation of Preoperative Neutrophil Lymphocyte Ratio as a Prognostic Factor in Hepatocellular Carcinoma
Utility and Limitation of Preoperative Neutrophil Lymphocyte Ratio as a Prognostic Factor in Hepatocellular Carcinoma
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DOI：
10.33160/yam.2018.12.002
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发表时间：
2018-12-01
影响因子：
1
通讯作者：
Fujiwara, Yoshiyuki
中科院分区：
文献类型：
--
作者：
Uchinaka, Ei;Amisaki, Masataka;Fujiwara, Yoshiyuki
背景 中性粒细胞淋巴细胞比率（NLR）已被提议作为炎症和免疫状态的替代标志物，并且在各种恶性肿瘤中具有预后价值。本研究旨在阐明术前 NLR 在肝细胞癌 (HCC) 中的预后意义。方法 我们招募了 135 名经组织学证实的 HCC 患者，并接受了初次根治性肝切除术。根据中位 NLR 值，将患者分为：NLR >= 2.0（NLR 高，n = 69）和 NLR < 2.0（NLR 低，n = 66）。 结果 在单变量分析中，5 年总生存率 (OS) 分别为 59.8 % +/- 6.7% 和 75.6% +/- 6.5% (P = 0.028)。 NLR 高和 NLR 低 分别为组。此外，NLR 高组和 NLR 低组的 5 年疾病特异性生存率分别为 68.6% +/- 6.7% 和 81.2 +/- 6.4% (P = 0.048)。 结论 我们的结果表明，高 NLR 是肝切除治疗的 HCC 中 OS 的独立预测因子，表明 NLR 可能是 HCC 的一种新型预后生物标志物。另一方面，NLR本身对HCC患者术后预后的预测也存在局限性。
Background The neutrophil lymphocyte ratio (NLR) has been proposed to be a surrogate marker of inflammation and immunological status and to have prognostic value in various malignancies. This study was conducted to clarify the prognostic significance of preoperative NLR in hepatocellular carcinoma (HCC).Methods We enrolled 135 patients with histologically-proven HCC who underwent initial curative hepatectomy. Based on the median NLR values, patients were divided into: NLR >= 2.0 (NLR-high, n = 69) and NLR < 2.0 (NLR-low, n = 66).Results In univariate analysis, the 5-year overall survival (OS) rates were 59.8 % +/- 6.7% and 75.6% +/- 6.5% (P = 0.028) in the NLR-high and NLR-low groups, respectively. Furthermore, the 5-year disease specific survival rates were 68.6% +/- 6.7%, and 81.2 +/- 6.4% (P = 0.048) in the NLR-high and NLR-low groups, respectively.Conclusion Our results showed that high NLR was an independent predictor for OS in hepatectomy-treated HCC, suggesting that NLR may be a novel prognostic biomarker for HCC. On the other hand, NLR also has a limitation to predict postoperative prognosis of HCC patients by itself.