Significance of Cancer Stem Cells in Anti-Cancer Therapies
Significance of Cancer Stem Cells in Anti-Cancer Therapies
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癌症干细胞在抗癌治疗中的意义
DOI：
10.17352/2455-8591.000010
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
H. Alves
中科院分区：
文献类型：
--
作者：
M. Botelho;H. Alves
干细胞是前沿研究的焦点，因为它们既有自我更新和增殖的能力，也有分化为各种组织的能力，在体外培养替代器官方面提供了诱人的前景，以及其他可能的治疗意义。可以想象，癌症干细胞有许多不同于正常组织的生物学特征，这些特征可能被利用来治疗。在这篇综述中，我们讨论了肿瘤干细胞在癌症诊断和预后以及抗癌药物设计新策略的开发中的意义。
Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacement organs in vitro, among other possible therapeutic implications. It is conceivable that cancer stem cells share a number of biological hallmarks that are different from their normal-tissue counterparts and that these might be taken advantage of for therapeutic benefits. In this review we discuss the significance of cancer stem cells in diagnosis and prognosis of cancer as well as in the development of new strategies for anti-cancer drug design.