Contribution of macromolecules to brain (1) H MR spectra: Experts' consensus recommendations.
Contribution of macromolecules to brain (1) H MR spectra: Experts' consensus recommendations.
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质子磁共振波谱的大脑，特别是那些在短期和中期回波时间测量，包含从移动的大分子（MM）的信号。主要MM的描述见本共识文件。MM的这些宽峰位于代谢物的较窄峰的基础上，通常使其定量复杂化，但它们也可能作为特定疾病的生物标志物具有潜在的重要性。因此，从低分子量代谢物中分离宽MM信号能够准确测定代谢物浓度，并且是许多研究的主要兴趣。其他研究试图了解MM光谱的起源，将其分解为单个光谱区域或峰，并将MM光谱的组分用作生物医学研究或临床实践中各种生理或病理状况的标志物。本共识文件的目的是提供关于如何在不同类型的研究中处理MM信号的概述和一些建议，以及该领域的未决问题列表，这些问题均在手稿结尾处进行了总结。
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low-molecular-weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field which are all summarized at the end of the manuscript.