Outcomes from a three-arm randomized controlled trial of frequent immersion in thermoneutral water on cardiovascular risk factors.
Outcomes from a three-arm randomized controlled trial of frequent immersion in thermoneutral water on cardiovascular risk factors.
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DOI：
10.1186/s12906-016-1241-7
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发表时间：
2016-07-27
影响因子：
--
通讯作者：
Huber R
中科院分区：
文献类型：
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作者：
Naumann J;Sadaghiani C;Bureau N;Schmidt S;Huber R
心血管疾病是全世界死亡的主要原因。温泉浴和浸泡在热中性水中（ITW）在治疗心血管危险因素方面有着悠久的历史。我们进行了一项三臂平行组随机对照研究，以调查频繁ITW对中度血压升高（BP）的影响。在这里，我们报告了次要结果，即浸泡在热中性水中对进一步的心血管危险因素的影响：体重指数（BMI），腰围，血脂，空腹血糖和C-反应蛋白。轻度至中度血压升高的患者（年龄57.6 ± 9.6岁，BMI 29.5 ± 5.7 kg/m2）在34.0-36.0 °C的热矿水池中接受ITW，每周4次，持续4周，每次45-60 min。一组（101）将强度降低到每周一次，持续20周，而另一组（102）继续每周洗澡四次。对照组被指示使用放松CD每周放松4次，每次45-60分钟，持续24周。意向治疗人群（N = 59）的次要分析显示，ITW治疗4周和24周后，轻度至中度血压升高的患者的BMI、腰围、血脂、空腹血糖或C反应蛋白均未显著降低。两组之间无显著差异。因此，我们没有发现证据支持我们的ITW计划是一种有效的干预措施，以诱导高血压患者的心血管变化。DRKS 00003980，见drks-neu.uniklinik-freiburg.de，德国临床试验注册中心（注册日期2012年7月10日）。本文的在线版本（doi：10.1186/s12906-016-1241-7）包含补充材料，可供授权用户使用。
Cardiovascular diseases are a main cause of mortality worldwide. Spa bathing and immersion in thermoneutral water (ITW) have a long history in the treatment of cardiovascular risk factors. We conducted a three-arm parallel-group, randomized controlled study to investigate the effects of frequent ITW on moderately elevated blood pressure (BP). Here, we report on the secondary outcomes, i.e. the influence of immersion in thermoneutral water on further cardiovascular risk factors: body mass index (BMI), waist circumference, blood lipids, fasting blood glucose and C-reactive protein. Patients (age 57.6 ± 9.6 years, BMI 29.5 ± 5.7 kg/m2) with mild to moderately elevated BP received ITW for 45–60 min in pools of thermal-mineral water at 34.0–36.0 °C four times a week for 4 weeks. One group (Bath1) reduced the intensity to one bath a week for a further 20 weeks, while the other group (Bath2) continued bathing four times a week. The control group was instructed to relax for 45–60 min four times a week for 24 weeks using a relaxation CD. The secondary analysis of the intention-to-treat population (N = 59) did not show a significant reduction of BMI, waist circumference, blood lipids, fasting blood glucose or C-reactive protein in patients with a mild to moderately elevated BP after 4 and 24 weeks ITW, respectively. There were no significant differences between the groups. Thus, we did not find evidence to support our ITW program being an efficacious intervention to induce cardiovascular alterations in this population of hypertensive patients. DRKS00003980 at drks-neu.uniklinik-freiburg.de, German Clinical Trials Register (registration date 2012-07-10). The online version of this article (doi:10.1186/s12906-016-1241-7) contains supplementary material, which is available to authorized users.