The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones
The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones
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DOI：
10.1016/s0304-3835(03)00410-5
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发表时间：
2003-10-08
期刊：
影响因子：
9.7
通讯作者：
Aikou, T
中科院分区：
文献类型：
--
作者：
Kijima, Y;Ishigami, S;Aikou, T
Epstein-Barr病毒（EBV）阳性和阴性胃癌（GC）的淋巴细胞浸润程度与预后的关系尚未完全评估。虽然ebv阳性GCs中浸润的CD8+ T细胞、自然杀伤细胞、树突状细胞、ki67阳性细胞的平均数量和级别明显高于阴性GCs，但ebv阳性组的生存率没有明显提高。这些发现提示EBV阳性胃癌中淋巴细胞的浸润并不一定意味着更好的预后，EBV状态并不是胃癌患者预后的重要因素。2003爱思唯尔爱尔兰有限公司版权所有。
The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+ T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer. (C) 2003 Elsevier Ireland Ltd. All rights reserved.