Transgenerational effects modulate density-dependent prophylactic resistance to viral infection in a lepidopteran pest.
Transgenerational effects modulate density-dependent prophylactic resistance to viral infection in a lepidopteran pest.
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跨代效应调节鳞翅目害虫对病毒感染的密度依赖性预防性抵抗力。
DOI：
10.1098/rsbl.2015.0012
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发表时间：
2015
期刊：
影响因子：
3.3
通讯作者：
Wilson K
中科院分区：
文献类型：
--
作者：
Wilson K
人们越来越认识到代际效应对后代健康的重要性，包括与免疫功能和抗病能力的关系。在这里，我们评估的影响，父母养育密度对后代抵抗病毒的挑战，在昆虫物种表达密度依赖性预防（DDP），即适应性增加的抵抗力或耐受性病原体感染，以应对拥挤。我们量化的存活率在幼虫的棉叶虫（Spodoptera littoralis）无论是群居或独居饲养的父母与杆状病毒的挑战。海牛核型多角体病毒幼虫从父母和后代表现出DDP，与群居饲养的幼虫具有较高的存活率比独居饲养的幼虫挑战后。然而，在这些类别中的每一个，感染后的存活率较低，在那些幼虫从群居饲养的父母比那些从孤独的饲养，DDP免疫上调的跨代成本一致。这一观察结果表明，拥挤的影响鳞翅目昆虫的抗病性在多个世代，与宿主-病原体相互作用的动态的潜在影响。
There is an increasing appreciation of the importance of transgenerational effects on offspring fitness, including in relation to immune function and disease resistance. Here, we assess the impact of parental rearing density on offspring resistance to viral challenge in an insect species expressing density-dependent prophylaxis (DDP); i.e. the adaptive increase in resistance or tolerance to pathogen infection in response to crowding. We quantified survival rates in larvae of the cotton leafworm (Spodoptera littoralis) from either gregarious- or solitary-reared parents following challenge with the baculovirusS. littoralisnucleopolyhedrovirus. Larvae from both the parental and offspring generations exhibited DDP, with gregarious-reared larvae having higher survival rates post-challenge than solitary-reared larvae. Within each of these categories, however, survival following infection was lower in those larvae from gregarious-reared parents than those from solitary-reared, consistent with a transgenerational cost of DDP immune upregulation. This observation demonstrates that crowding influences lepidopteran disease resistance over multiple generations, with potential implications for the dynamics of host–pathogen interactions.