Effects of nimodipine on cerebral vasoconstrictor responses.
Effects of nimodipine on cerebral vasoconstrictor responses.
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尼莫地平对脑血管收缩反应的影响。
DOI：
10.1152/ajpheart.1984.247.2.h170
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Heistad,DD
中科院分区：
文献类型：
--
作者：
Haws,CW;Heistad,DD
本研究旨在观察钙拮抗剂尼莫地平（Baye 9736）对在体脑血管收缩反应的影响。在麻醉猫中测量软膜动脉直径。在对照状态下，交感神经刺激、急性高血压和低碳酸血症分别使软脑膜动脉直径最大降低13.7 +/- 1.4、12.1 +/- 2.7和13.3 +/- 2.7%（SE）。低剂量尼莫地平（0.1-0.25 μ g × kg ~（-1）× min ~（-1））降低了对所有三种刺激的血管收缩反应，而高剂量（0.5-1.0）几乎消除了这种反应（与对照组相比，P <0.05）。在猫和猴子的其他实验中，在动脉压急性升高期间用微球测量脑血流量（CBF）。在对照状态下，猫动脉压升高约40 mmHg仅使CBF从48 +/- 3增加至57 +/- 3 ml X min-1 X 100 g-1，尼莫地平治疗期间CBF从53 +/- 6增加至87 +/- 9 ml X min-1 X 100 g-1（P <0.05，对照组与尼莫地平组）。尼莫地平也抑制猴的血管自动调节收缩。尼莫地平，在使用的剂量，只有适度的影响，静息血管直径，CBF，或动脉压。我们得出结论，尼莫地平抑制脑血管收缩反应的几种生理刺激在体内。
The purpose of this study was to examine effects of nimodipine (Bay e 9736), a calcium blocker, on constrictor responses of cerebral vessels in vivo. Pial artery diameter was measured in anesthetized cats. In the control state, sympathetic nerve stimulation, acute hypertension, and hypocapnia produced maximal decreases in pial artery diameter of 13.7 +/- 1.4, 12.1 +/- 2.7, and 13.3 +/- 2.7% (SE), respectively. Low doses of nimodipine (0.1-0.25 microgram X kg-1 X min-1) decreased the vasoconstrictor response to all three stimuli, and higher doses (0.5-1.0) virtually abolished the response (P less than 0.05 vs. control). In other experiments in cats and monkeys, cerebral blood flow (CBF) was measured with microspheres during acute increases in arterial pressure. Elevation of arterial pressure by approximately 40 mmHg in cats produced only a modest increase in CBF from 48 +/- 3 to 57 +/- 3 ml X min-1 X 100 g-1 in the control state and a larger increase in CBF from 53 +/- 6 to 87 +/- 9 ml X min-1 X 100 g-1 during nimodipine (P less than 0.05, control vs. nimodipine). Nimodipine also inhibited autoregulatory vasoconstriction in monkeys. Nimodipine, in the doses used, had only modest effects on resting vessel diameter, CBF, or arterial pressure. We conclude that nimodipine inhibits cerebral vasoconstrictor responses to several physiological stimuli in vivo.