Jejunal regulation of gastric motility patterns: effect of extrinsic neural continuity to stomach.
Jejunal regulation of gastric motility patterns: effect of extrinsic neural continuity to stomach.
复制标题
胃运动模式的空肠调节：外在神经连续性对胃的影响。
DOI：
10.1152/ajpgi.1990.258.1.g32
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hakim,NS
中科院分区：
文献类型：
--
作者：
Spencer,MP;Sarr,MG;Soper,NJ;Hakim,NS
本研究旨在确定外源性胃神经支配在介导空肠灌注混合营养素对犬消化间期胃运动模式的抑制作用中的作用。四只狗进行了横切所有外在和内在的神经连续性的胃，除了小心保存迷走神经支配（阶段1）。放置胃窦测压导管、胃窦电极、肠电极和空肠灌注导管。恢复2周后，在以2.9 ml/min的速度将非营养性NaCl（150 mM）或混合营养物（50% Meritene溶液）的等摩尔溶液输注至空肠6 h期间，记录了禁食期间胃和小肠肌电和收缩活动的第1阶段研究。相同的研究（第2阶段）重复后，完成了外源性去神经支配的胃膈上迷走神经。在第1阶段的研究中，空肠营养素（83千卡/小时）抑制特征消化间期循环运动模式在胃和十二指肠大于或等于172分钟，在空肠灌注混合营养素。在完成外源性去神经支配（第2阶段）后，空肠输注营养物质具有与抑制胃和小肠的周期性运动模式相同的效果。我们的结论是，空肠注入营养物质的消化间期胃动力模式的抑制是由激素机制介导的，而不是由非迷走神经或迷走神经的外源性神经输入到胃。
This study was designed to determine the role of extrinsic gastric innervation in mediating the inhibitory effects of jejunal infusion of mixed nutrients on canine interdigestive gastric motility patterns. Four dogs underwent transection of all extrinsic and intrinsic neural continuity to the stomach except for careful preservation of vagal innervation (stage 1). Antral manometry catheters, antral electrodes, intestinal electrodes, and a jejunal infusion catheter were placed. After a 2-wk recovery, stage 1 studies of myoelectric and contractile activity of the stomach and small bowel during fasting were recorded on four occasions during infusion of isomolar solutions of either nonnutrient NaCl (150 mM) or mixed nutrients (50% Meritene solution) into the jejunum at 2.9 ml/min for 6 h. Identical studies (stage 2) were repeated after completion of extrinsic denervation of the stomach by supradiaphragmatic vagotomy. In stage 1 studies, jejunal nutrients (83 kcal/h) inhibited the characteristic interdigestive cyclic motility patterns in the stomach and duodenum for greater than or equal to 172 min during jejunal infusion of mixed nutrients. After completion of extrinsic denervation (stage 2), jejunal infusion of nutrients had the same effects with inhibition of cyclic motility patterns in the stomach and small intestine. We concluded that inhibition of interdigestive gastric motility patterns by jejunally infused nutrients is mediated by hormonal mechanisms and not by nonvagal or vagal extrinsic neural input to the stomach.