Genome-wide evidence for speciation with gene flow in Heliconius butterflies.
Genome-wide evidence for speciation with gene flow in Heliconius butterflies.
复制标题
DOI：
10.1101/gr.159426.113
复制
发表时间：
2013-11
期刊：
影响因子：
7
通讯作者：
Jiggins CD
中科院分区：
文献类型：
--
作者：
Martin SH;Dasmahapatra KK;Nadeau NJ;Salazar C;Walters JR;Simpson F;Blaxter M;Manica A;Mallet J;Jiggins CD
大多数物种形成事件可能是逐渐发生的，没有完全和立即的生殖隔离，但在整个基因组范围内，很少有人描述不同物种之间基因流动的全部范围。记录不同物种之间混合的程度和时间可以澄清地理隔离在物种形成中的作用。在这里，我们使用新的方法，基于31个个体的全基因组序列，对赫利柯斯蝴蝶不同发散阶段的混合进行量化。在共生种群和异地种群之间的比较显示，在全基因组范围内，共生变异增加的趋势表明，普遍存在种间基因流动。高达40%的100kb基因组窗口按地理而不是按物种聚集，表明很大一部分基因组在共处的物种之间共享。对不同时间间隔共有的遗传变异的分析表明，这些物种之间的混合自物种形成早期以来一直在继续。物种间共享的等位基因在最近的时间间隔内表现出比在较长时间间隔内共享的等位基因更高的连锁不平衡水平，这表明这种混合发生在分歧期间的多个点上，并且可能正在进行。在控制发散翅型的基因座附近以及整个Z染色体上，杂交信号显著降低，这与缪勒拟态的强烈选择和已知的Z连锁杂交不亲和性是一致的。总体而言，这些结果表明，面对长期持续的全基因组混合，物种分化可能会发生。
Most speciation events probably occur gradually, without complete and immediate reproductive isolation, but the full extent of gene flow between diverging species has rarely been characterized on a genome-wide scale. Documenting the extent and timing of admixture between diverging species can clarify the role of geographic isolation in speciation. Here we use new methodology to quantify admixture at different stages of divergence in Heliconius butterflies, based on whole-genome sequences of 31 individuals. Comparisons between sympatric and allopatric populations of H. melpomene, H. cydno, and H. timareta revealed a genome-wide trend of increased shared variation in sympatry, indicative of pervasive interspecific gene flow. Up to 40% of 100-kb genomic windows clustered by geography rather than by species, demonstrating that a very substantial fraction of the genome has been shared between sympatric species. Analyses of genetic variation shared over different time intervals suggested that admixture between these species has continued since early in speciation. Alleles shared between species during recent time intervals displayed higher levels of linkage disequilibrium than those shared over longer time intervals, suggesting that this admixture took place at multiple points during divergence and is probably ongoing. The signal of admixture was significantly reduced around loci controlling divergent wing patterns, as well as throughout the Z chromosome, consistent with strong selection for Müllerian mimicry and with known Z-linked hybrid incompatibility. Overall these results show that species divergence can occur in the face of persistent and genome-wide admixture over long periods of time.
登录
查看更多内容
影响因子：
64.8
作者：
Dasmahapatra, Kanchon K.;Walters, James R.;Briscoe, Adriana D.;Davey, John W.;Whibley, Annabel;Nadeau, Nicola J.;Zimin, Aleksey V.;Hughes, Daniel S. T.;Ferguson, Laura C.;Martin, Simon H.;Salazar, Camilo;Lewis, James J.;Adler, Sebastian;Ahn, Seung-Joon;Baker, Dean A.;Baxter, Simon W.;Chamberlain, Nicola L.;Chauhan, Ritika;Counterman, Brian A.;Dalmay, Tamas;Gilbert, Lawrence E.;Gordon, Karl;Heckel, David G.;Hines, Heather M.;Hoff, Katharina J.;Holland, Peter W. H.;Jacquin-Joly, Emmanuelle;Jiggins, Francis M.;Jones, Robert T.;Kapan, Durrell D.;Kersey, Paul;Lamas, Gerardo;Lawson, Daniel;Mapleson, Daniel;Maroja, Luana S.;Martin, Arnaud;Moxon, Simon;Palmer, William J.;Papa, Riccardo;Papanicolaou, Alexie;Pauchet, Yannick;Ray, David A.;Rosser, Neil;Salzberg, Steven L.;Supple, Megan A.;Surridge, Alison;Tenger-Trolander, Ayse;Vogel, Heiko;Wilkinson, Paul A.;Wilson, Derek;Yorke, James A.;Yuan, Furong;Balmuth, Alexi L.;Eland, Cathlene;Gharbi, Karim;Thomson, Marian;Gibbs, Richard A.;Han, Yi;Jayaseelan, Joy C.;Kovar, Christie;Mathew, Tittu;Muzny, Donna M.;Ongeri, Fiona;Pu, Ling-Ling;Qu, Jiaxin;Thornton, Rebecca L.;Worley, Kim C.;Wu, Yuan-Qing;Linares, Mauricio;Blaxter, Mark L.;Ffrench-Constant, Richard H.;Joron, Mathieu;Kronforst, Marcus R.;Mullen, Sean P.;Reed, Robert D.;Scherer, Steven E.;Richards, Stephen;Mallet, James;McMillan, W. Owen;Jiggins, Chris D.
通讯作者：
Jiggins, Chris D.
影响因子：
10.7
作者：
Charlesworth, B
通讯作者：
Charlesworth, B
影响因子：
3.3
作者：
Gagnaire, Pierre-Alexandre;Pavey, Scott A.;Bernatchez, Louis
通讯作者：
Bernatchez, Louis
影响因子：
7
作者：
Lunter, Gerton;Goodson, Martin
通讯作者：
Goodson, Martin
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--