The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function.
The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function.
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DOI：
10.1016/j.ceb.2008.03.015
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发表时间：
2008-08
影响因子：
7.5
通讯作者：
Futai M
中科院分区：
文献类型：
--
作者：
Marshansky V;Futai M
胞浆型H+-ATP酶（V-ATP酶）驱动的质子泵和细胞器酸化是真核细胞胞吐和胞吞两条途径中囊泡运输沿着所必需的。V-ATP酶功能缺陷和囊泡酸化缺陷已被认为是多种人类疾病的重要机制，并正在成为潜在的治疗靶点。在过去的几年中，我们在理解V-ATP酶的功能、调节和细胞生物学作用方面取得了重大进展。在这里，我们将回顾这些研究，重点是新的V-ATP酶在调节囊泡运输事件的直接作用。
Vacuolar-type H+-ATPase (V-ATPase)-driven proton pumping and organellar acidification is essential for vesicular trafficking along both the exocytotic and endocytotic pathways of eukaryotic cells. Deficient function of V-ATPase and defects of vesicular acidification have been recently recognized as important mechanisms in a variety of human diseases and are emerging as potential therapeutic targets. In the past few years, significant progress has been made in our understanding of function, regulation, and the cell biological role of V-ATPase. Here, we will review these studies with emphasis on novel direct roles of V-ATPase in the regulation of vesicular trafficking events.
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影响因子：
30.8
作者：
Frattini, A;Orchard, PJ;Villa, A
通讯作者：
Villa, A
DOI：
10.1083/jcb.200212004
发表时间：
2003-07-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bayer MJ;Reese C;Buhler S;Peters C;Mayer A
通讯作者：
Mayer A
影响因子：
5.5
作者：
El Annan, J;Brown, D;Marshansky, V
通讯作者：
Marshansky, V
影响因子：
21.3
作者：
Hurtado-Lorenzo, A;Skinner, M;Marshansky, V
通讯作者：
Marshansky, V
影响因子：
4.8
作者：
Hirata, T;Iwamoto-Kihara, A;Futai, M
通讯作者：
Futai, M