Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma.
Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma.
复制标题
DOI：
10.1186/1746-160x-4-17
复制
发表时间：
2008-07-31
影响因子：
3
通讯作者：
Kosmehl, Hartwig
中科院分区：
文献类型：
--
作者：
Driemel, Oliver;Muller-Richter, Urs D A;Kosmehl, Hartwig
背景：棘层松解性鳞状细胞癌和口腔内血管肉瘤具有相似的组织病理学特征。本研究的目的是找到一个明确的differentiation.METHODS标记：四口腔棘层松解性鳞状细胞癌和口腔内血管肉瘤是用来比较的发疹性口腔内生长模式，年龄高峰，预后不良和裂缝样瘤内空间在共同的组织学染色作为相同的临床和组织病理学特征。免疫组化染色检测pancytokeratin、cytokeratin、collagen type IV、laminin-5 γ 2-chain、endothelial differentiation marker CD 31和CD 34、F VIII相关抗原、Ki 67抗原、β-catenin、E-cadherin、α-smooth-muscle-actin和Fli-1。ASCC的大血管化使血管肉瘤的特征性血管鉴别标志物的解释复杂化。细胞-细胞粘附的丧失，通过E-cadherin和β-catenin膜染色的丧失来监测，被确定为ASCC中侵袭因子ln-5大量表达的原因，并被认为是ASCC预后不良的原因。Fli-1在血管肉瘤中的表达和ln-5在ASCC中的细胞免疫反应可作为两者的鉴别特征。
BACKGROUND: acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction.METHODS: Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, gamma2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, beta-catenin, E-cadherin, alpha-smooth-muscle-actin and Fli-1 were done.RESULTS: Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and beta-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities.CONCLUSION: Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.