Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study.
Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study.
复制标题
人类大脑皮层从童年到青年期谷氨酸的成熟减少：1H-MR 光谱研究。
DOI：
10.1038/pr.2017.101
复制
发表时间：
2017
期刊：
影响因子：
3.6
通讯作者：
Nakada T.
中科院分区：
文献类型：
--
作者：
Shimizu M;Suzuki Y;Yamada K;Ueki S;Watanabe M;Igarashi H;Nakada T.
BackgroundThe本研究的目的是探讨成熟的变化，谷氨酸（Glu）在人类大脑皮层从儿童到青年使用3.0特斯拉质子磁共振波谱（1 H-MRS），这是能够量化Glu在vivo.MethodsNormal志愿者，包括11名儿童（4-13岁）和11名年轻人（18-33岁）参加了这项研究。单体素点分辨光谱（PRESS，重复时间/回波时间= 2,000/80毫秒）进行了额叶和枕叶皮质，谷氨酸肌酸比（Glu/Cr）和N-乙酰天冬氨酸肌酸比（NAA/Cr）determined.ResultsIn两个额叶和枕叶皮质，Glu/Cr是显着降低，在年轻的成年期相对于在儿童时期。NAA/Cr没有显着差异两个年龄组之间。ConclusionThis研究提供了客观证据，大脑皮层Glu/Cr降低儿童和青年成人之间。观察到的Glu/Cr降低可能反映了同时发生的成熟变化，如皮质微结构的变化和Glu代谢的细胞间区室化。
BackgroundThe aim of the present study was to investigate maturational changes in glutamate (Glu) in the human cerebral cortex from childhood to young adulthood using 3.0-Tesla proton magnetic resonance spectroscopy (1 H-MRS), which is capable of quantifying Glu in vivo.MethodsNormal volunteers comprising 11 children (aged 4–13 years) and 11 young adults (aged 18–33 years) participated in the study. Single-voxel point-resolved spectroscopy (PRESS, repetition time/echo time= 2,000/80 ms) was performed on the frontal and occipital cortices, and the Glu-to-creatine ratio (Glu/Cr) and N-acetylaspartate-to-creatine ratio (NAA/Cr) were determined.ResultsIn both the frontal and occipital cortices, Glu/Cr was significantly lower during young adulthood relative to that during childhood. NAA/Cr did not differ significantly between the two age groups.ConclusionThis study has provided objective evidence that cerebral cortical Glu/Cr decreases between childhood and young adulthood. The observed decrease in Glu/Cr may reflect the simultaneous occurrence of maturational changes, such as changes in cortical microstructure and the intercellular compartmentation of Glu metabolism.