Generation of bilateral symmetry in Anthozoa: A model
Generation of bilateral symmetry in Anthozoa: A model
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DOI：
10.1016/j.jtbi.2007.01.008
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发表时间：
2007-06-07
影响因子：
2
通讯作者：
Berking, Stefan
中科院分区：
文献类型：
--
作者：
Berking, Stefan
珊瑚虫类的息肉通常显示两侧对称，相对于他们的嘴开口，他们的咽，特别是他们的肠系膜的安排。肠系膜是从胃体顶端延伸到胃体基端的内胚层褶皱，将胃腔细分为胃袋。它们形成双边对称序列。在这篇文章中，我提出，在息肉发展的早期，内胚层依次细分成三种不同类型的隔间。在隔室之间的边界处形成肠系膜。其中两个隔间与Scyphozoa的隔间同源。它们是通过局部相互排斥的细胞状态的相互激活而形成的。第三个隔间导致管舌藻的形成，是珊瑚虫的进化创新。控制第三类隔室数量和空间排列的机制将径向对称变为双侧对称，偶尔也变为不同的对称。其形成的动力学表明激活剂-抑制剂机制。提供了计算机模型，其再现了肠系膜生成中的决策步骤。(C)2007爱思唯尔有限公司保留所有权利。
Polyps of Anthozoa usually display bilateral symmetry with respect to their mouth opening, to their pharynx, and in particular to the arrangement of their mesenteries. Mesenteries, which are endodermal folds running from the apical to the basal end of the body, subdivide the gastric cavity into pouches. They form in a bilateral symmetric sequence. In this article I propose that early in polyp development the endoderm subdivides successively into three different types of compartments. A mesentery forms at the border between compartments. Two of the compartments are homologous to those of Scyphozoa. They form by mutual activation of cell states that locally exclude each other. The third compartment leads to siphonoglyph formation and is an evolutionary innovation of the Anthozoa. The mechanism that controls the number and spatial arrangement of the third type of compartment changes the radial symmetry into a bilateral one and occasionally into a different one. The dynamics of its formation indicate an activator-inhibitor mechanism. Computer models are provided that reproduce decision steps in the generation of the mesenteries. (C) 2007 Elsevier Ltd. All rights reserved.