PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases.
PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases.
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PPAR作为肝脏疾病的代谢感受器和治疗靶点。
DOI：
10.3390/ijms22158298
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发表时间：
2021-08-02
影响因子：
5.6
通讯作者：
Armendariz-Borunda J
中科院分区：
文献类型：
--
作者：
Monroy-Ramirez HC;Galicia-Moreno M;Sandoval-Rodriguez A;Meza-Rios A;Santos A;Armendariz-Borunda J
碳水化合物和脂质是饮食的两个组成部分，它们提供必要的能量来进行各种生理过程，以帮助维持体内的稳态。然而，当两种生物分子的代谢发生改变时，就会发生各种肝脏疾病。例如代谢相关脂肪肝病 (MAFLD)、乙型和丙型肝炎病毒感染、酒精性肝病 (ALD)，以及更严重的情况下的肝细胞癌 (HCC)。另一方面，PPAR 是配体依赖性转录因子家族，在肝脏水平以及其他器官的代谢过程调节中发挥着重要作用。与特定配体相互作用后，PPAR 易位至细胞核，发生结构变化以调节参与脂质代谢、脂肪生成、炎症和代谢稳态的基因转录。本综述旨在提供有关 PPAR 在肝脏代谢调节中的关键作用及其参与引发多种肝脏疾病的最新数据。提供了有关其分子特征、细胞信号通路以及调节其功能的主要药理疗法（目前从事临床情况或药理开发）的信息。
Carbohydrates and lipids are two components of the diet that provide the necessary energy to carry out various physiological processes to help maintain homeostasis in the body. However, when the metabolism of both biomolecules is altered, development of various liver diseases takes place; such as metabolic-associated fatty liver diseases (MAFLD), hepatitis B and C virus infections, alcoholic liver disease (ALD), and in more severe cases, hepatocelular carcinoma (HCC). On the other hand, PPARs are a family of ligand-dependent transcription factors with an important role in the regulation of metabolic processes to hepatic level as well as in other organs. After interaction with specific ligands, PPARs are translocated to the nucleus, undergoing structural changes to regulate gene transcription involved in lipid metabolism, adipogenesis, inflammation and metabolic homeostasis. This review aims to provide updated data about PPARs’ critical role in liver metabolic regulation, and their involvement triggering the genesis of several liver diseases. Information is provided about their molecular characteristics, cell signal pathways, and the main pharmacological therapies that modulate their function, currently engaged in the clinic scenario, or in pharmacological development.
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