Nanoparticles: Cellular Uptake and Cytotoxicity
Nanoparticles: Cellular Uptake and Cytotoxicity
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DOI：
10.1007/978-94-017-8739-0_5
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Labhasetwar, Vinod
中科院分区：
文献类型：
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作者：
Adjei, Isaac M.;Sharma, Blanka;Labhasetwar, Vinod
了解纳米粒子与细胞的相互作用以及这些相互作用如何影响细胞摄取，对于探索纳米粒子的生物医学应用，特别是药物输送是至关重要的。各种因素，无论是NPs物理性质的差异还是细胞-膜特性的变化，都会影响NP-细胞的相互作用和摄取过程。NP-细胞膜的相互作用也可能影响NPs在细胞内的运输，它们被分选到不同的细胞内，细胞滞留，从而影响微囊化疗法的疗效。一个关键的考虑是，这种相互作用是否可能造成任何毒性，首先是NPs在与目标细胞和组织相互作用之前，在运输过程中如何与生物环境相互作用。了解NP的各种特性对细胞和生物过程的影响有助于设计高效但无毒的NPs。
Understanding the interactions of nanoparticles (NPs) with cells and how these interactions influence their cellular uptake is essential to exploring the biomedical applications of NPs, particularly for drug delivery. Various factors, whether differences in physical properties of NPs or variations in cell-membrane characteristics, influence NP-cell interactions and uptake processes. NP-cell membrane interactions may also influence intracellular trafficking of NPs, their sorting into different intracellular compartments, cellular retention, and hence the efficacy of encapsulated therapeutics. A crucial consideration is whether such interactions might cause any toxicity, starting with how NPs interact in transit with the biological environment prior to their interactions with targeted cells and tissues. Understanding the effects of various NP characteristics on cellular and biological processes could help in designing NPs that are efficient but also nontoxic.