Divergent Aerobic Oxidative Ring-Opening Cascades of Isatins with 1,2,3,4-Tetrahydroisoquinoline
Divergent Aerobic Oxidative Ring-Opening Cascades of Isatins with 1,2,3,4-Tetrahydroisoquinoline
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靛红与 1,2,3,4-四氢异喹啉的发散需氧氧化开环级联
DOI：
10.1002/ejoc.201601037
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发表时间：
2016
影响因子：
2.8
通讯作者：
Yang Hua
中科院分区：
文献类型：
--
作者：
Xia Peng-Ju;Xiao Jun-An;Sun Yan-Hua;Li Jun;Xiang Hao-Yue;Chen Xiao-Qing;Yang Hua
探索了靛红与 1,2,3,4-四氢异喹啉前所未有的有氧氧化开环引发级联，其中只需在靛红中引入保护基即可轻松调节反应顺序。因此，具有潜在生物活性的喹唑啉-2,4-二酮和多环2,3-二氢-4(1H)-喹唑啉酮以中等化学产率有效组装。
The unprecedented aerobic oxidative ring‐opening‐initiated cascades of isatins with 1,2,3,4‐tetrahydroisoquinoline were explored, in which the reaction sequence could be readily modulated by simply introducing a protecting group in the isatin. Consequently, quinazoline‐2,4‐diones and polycyclic 2,3‐dihydro‐4(1H)‐quinazolinones with potential bioactivities were efficiently assembled in moderate chemical yields.