Vitamin E and the oxidative stress of exercise
Vitamin E and the oxidative stress of exercise
复制标题
DOI：
10.1196/annals.1331.015
复制
发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
McArdle, A
中科院分区：
文献类型：
--
作者：
Jackson, MJ;Khassaf, M;McArdle, A
有明确的证据表明，收缩骨骼肌产生一组复杂的活性氧和氮物质，并且这种产生的模式和幅度受到肌肉收缩方案的类型和频率的影响。这些物种在运动生物体中的功能尚不清楚，尽管已有数据表明它们在收缩引起的肌肉损伤和/或收缩的信号适应性反应中发挥作用。维生素E被认为对收缩诱导的氧化剂的作用有调节作用已经有相当长的一段时间了，尽管缺乏在这一领域发挥任何特定作用的证据。这方面的研究综述表明，维生素E补充剂不太可能可靠地降低收缩引起的肌肉损伤的严重程度，但相反，似乎能够调节氧化还原调节的适应性反应收缩。全面评估氧化剂和抗氧化剂（如维生素E）在肌肉收缩反应中的作用，应能操纵这些过程，对维持最佳肌肉功能具有潜在的有益作用。
There is clear evidence that contracting skeletal muscle generates a complex set of reactive oxygen and nitrogen species and that the pattern and magnitude of this generation is influenced by the type and frequency of the muscle contraction protocol. The functions of these species in exercising organisms are still unclear although data have been presented indicating that they play a role in contraction-induced muscle damage and/or in signaling adaptive responses to contractions. Vitamin E has been claimed to exert a regulatory effect on the actions of contraction-induced oxidants for a considerable time, although evidence for any specific role in this area is lacking. A review of studies in this area suggests that vitamin E supplements are unlikely to reliably reduce the severity of contraction-induced muscle damage but, in contrast, appear capable of modulating redox-regulated adaptive responses to contractions. Full evaluation of the roles of oxidants and antioxidants such as vitamin E in responses of muscle to contractions should enable the manipulation of these processes with potential beneficial effects on maintenance of optimal muscle function.