Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians
Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians
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DOI：
10.1037/0033-2909.132.4.607
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发表时间：
2006-07-01
影响因子：
22.4
通讯作者：
Wall, Tamara L.
中科院分区：
文献类型：
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作者：
Luczak, Susan E.;Glatt, Stephen J.;Wall, Tamara L.
进行荟萃分析，以确定2个基因，ALDH 2和ADH 1B，与亚洲人酒精依赖的多态性之间的关系的大小。对于每一个基因，拥有第一个 *2等位基因的变体是对酒精依赖的保护，拥有第二个 *2等位基因并没有提供显着的额外保护。这两个基因多态性的保护作用是独立的。诊断标准、招募策略和日本种族调节了ALDH 2 *2的作用。招募策略和性别对ADH 1B *2的影响具有调节作用。这些发现强调了方法问题的重要性，以及在研究遗传多态性和表型之间的关系时必须考虑的潜在基因-基因和基因-环境相互作用。
Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of I variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.