Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes.
Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes.
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DOI：
10.1007/s00198-011-1807-7
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发表时间：
2012-06
影响因子：
4
通讯作者：
Fowlkes, J. L.
中科院分区：
文献类型：
--
作者：
Thrailkill, K. M.;Jo, C. -H.;Cockrell, G. E.;Moreau, C. S.;Lumpkin, C. K., Jr.;Fowlkes, J. L.
To determine whether dysregulation of circulating concentrations of undercarboxylated osteocalcin (UC-OC) or GLA-carboxylated osteocalcin (GLA-OC) occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance. We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with type 1 diabetes (T1D), ages 14–40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender, age), indices of glycemic control (HbA1c, fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis [Total calcium, 25-OH vitamin D, parathyroid hormone, IGF-I, type 1 collagen degradation fragments (CTX), adiponectin, leptin] were examined. Between group differences in the concentrations of UC-OC and GLA-OC were the main outcome measures. Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UC-OC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p<0.001), higher CTX (p<0.001), lower HbA1c (p=0.013) and higher IGF-I (p=0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide: Glucose ratio (reflecting endogenous insulin secretion); with IGF-I (reflecting intra-portal insulin sufficiency); and with total daily insulin dose. In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.
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影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
1.8
作者：
Brophy S;Davies H;Stephens JW;Prior SL;Atkinson M;Bain S;Williams R
通讯作者：
Williams R
影响因子：
8
作者：
Hwang, You-Cheol;Jeong, In-Kyung;Chung, Ho Yeon
通讯作者：
Chung, Ho Yeon
影响因子：
4.1
作者：
Nyman, Jeffry S.;Even, Jesse L.;Jo, Chan-Hee;Herbert, Erik G.;Murry, Matthew R.;Cockrell, Gael E.;Wahl, Elizabeth C.;Bunn, R. Clay;Lumpkin, Charles K., Jr.;Fowlkes, John L.;Thrailkill, Kathryn M.
通讯作者：
Thrailkill, Kathryn M.