Cyclic-di-GMP regulation of virulence in bacterial pathogens
Cyclic-di-GMP regulation of virulence in bacterial pathogens
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DOI：
10.1002/wrna.1454
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发表时间：
2018-01-01
影响因子：
7.3
通讯作者：
Lee, Vincent T.
中科院分区：
文献类型：
--
作者：
Hall, Cherisse L.;Lee, Vincent T.
信号通路使细菌能够适应不断变化的环境。对于致病性细菌，信号传导途径允许在哺乳动物宿主内及时表达毒力因子和抑制抗病力因子。当细菌离开哺乳动物宿主时，信号传导途径使得能够表达促进在环境和/或非哺乳动物宿主中存活的因子。一种这样的信号传导途径使用二核苷酸环状二GMP（c-di-GMP），并且许多细菌基因组编码负责合成和降解c-di-GMP的许多蛋白质。一旦产生，c-di-GMP结合到单个蛋白质和RNA受体上，以变构方式改变大分子功能，从而驱动表型变化。每个细菌基因组编码用于c-di-GMP信号传导和毒力因子的独特基因组，因此c-di-GMP的调节是生物体特异性的。最近的工作已经指出的证据表明，c-di-GMP调节哺乳动物宿主的不同细菌病原体的毒力。在这篇综述中，我们讨论的标准确定的贡献，信号核苷酸的发病机制，使用一个良好的特征信号核苷酸，环腺苷酸（cAMP），在铜绿假单胞菌。使用这些标准，我们审查的c-di-GMP介导的毒力的作用，并强调共同的主题，存在于八种不同的病原体，通过不同的感染和传播途径引起不同的疾病。（C）2017 Wiley Periodicals，Inc.
Signaling pathways allow bacteria to adapt to changing environments. For pathogenic bacteria, signaling pathways allow for timely expression of virulence factors and the repression of antivirulence factors within the mammalian host. As the bacteria exit the mammalian host, signaling pathways enable the expression of factors promoting survival in the environment and/or nonmammalian hosts. One such signaling pathway uses the dinucleotide cyclic-di-GMP (c-di-GMP), and many bacterial genomes encode numerous proteins that are responsible for synthesizing and degrading c-di-GMP. Once made, c-di-GMP binds to individual protein and RNA receptors to allosterically alter the macromolecule function to drive phenotypic changes. Each bacterial genome encodes unique sets of genes for c-di-GMP signaling and virulence factors so the regulation by c-di-GMP is organism specific. Recent works have pointed to evidence that c-di-GMP regulates virulence in different bacterial pathogens of mammalian hosts. In this review, we discuss the criteria for determining the contribution of signaling nucleotides to pathogenesis using a well-characterized signaling nucleotide, cyclic AMP (cAMP), in Pseudomonas aeruginosa. Using these criteria, we review the roles of c-di-GMP in mediating virulence and highlight common themes that exist among eight diverse pathogens that cause different diseases through different routes of infection and transmission. (C ) 2017 Wiley Periodicals, Inc.