Action of ATP on ventricular automaticity.
Action of ATP on ventricular automaticity.
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ATP 对心室自动性的作用。
DOI：
10.1097/00005344-199424050-00008
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发表时间：
1994
影响因子：
3
通讯作者：
H. Tritthart
中科院分区：
文献类型：
--
作者：
G. Stark;H. Domanowits;F. Sterz;U. Stark;M. Bachernegg;E. Kickenweiz;M. Decrinis;A. Laggner;H. Tritthart
当房室结是折返环的一部分时，ATP是室上性心动过速的有效治疗方法。然而，起搏器层级中的起搏器越低，它对腺苷越敏感。因此，我们研究了ATP在体内和体外条件下对心室自律性的影响。46例宽、窄QRS波群心动过速患者分别用ATP 6、12和18 mg序贯静脉注射（i. v.）推注。ATP终止了67%的心动过速。大剂量输注ATP导致自限性心搏停止≤ 6.4 s。用100 μ M ATP灌注离体自发搏动的豚鼠心脏完全抑制心室自律性。停止ATP输注后，第一次心室搏动在3.1 +/- 0.9 s后明显，窦房结活动恢复，时间常数为3.0 +/- 1.1 s。由于窦房结和心室自律性在体外停止ATP输注后几秒钟内恢复，因此体内恢复也可能由ATP的短半衰期（+1/2）决定。
ATP is an effective treatment of supraventricular tachycardia when the atrioventricular (AV) node is part of the reentrant circuit. However, the lower a pace-maker in the pacemaker hierarchy, the more sensitive it is to adenosine. Therefore, we investigated the effects of ATP on ventricular automaticity in in vivo and in vitro conditions. Wide and narrow QRS complex tachycardia in 46 patients was treated with 6, 12, and 18 mg ATP as sequential intravenous (i.v.) bolus. ATP terminated tachycardias in 67%. Bolus infusion ATP caused < or = 6.4-s asystole that was self-limited. Perfusion of isolated spontaneously beating guinea pig heart with 100 microM ATP completely suppressed ventricular automaticity. After ATP-infusion was discontinued, the first ventricular beat was evident after 3.1 +/- 0.9 s and sinus node activity recovered with a time constant of 3.0 +/- 1.1 s. Because sinus node and ventricular automaticity recovered within seconds after ATP infusion was discontinued in vitro, recovery in vivo is also likely to be determined by the short half-life (+1/2) of ATP.