Cerebellar involvement in cognitive flexibility
Cerebellar involvement in cognitive flexibility
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DOI：
10.1016/j.nlm.2009.03.008
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发表时间：
2009-10-01
影响因子：
2.7
通讯作者：
Petrosini, L.
中科院分区：
文献类型：
--
作者：
De Bartolo, P.;Mandolesi, L.;Petrosini, L.
本研究的目的是探讨小脑结构是否参与需要认知灵活性的功能。研究了半小脑切除动物和对照动物在学习四选项学习任务时适应不断变化的反应规则的灵活性。虽然在任务的初始阶段，两个实验组都表现出相似的表现，但随着时间的推移，只有对照动物的表现显著提高。受损动物的表现缺乏改善，使得它们在任务的最后阶段的反应特别有缺陷，而相反，完好无损的动物表现得最好，利用了它们的“学会学习”能力。研究结果表明，小脑损伤对新反应的获得，而不是执行有缺陷的影响。研究结果强调了小脑在调节认知灵活性行为中的重要作用。(C) 2009爱思唯尔公司版权所有。
The aim of the present study was to investigate whether the cerebellar structures are involved in functions requiring cognitive flexibility abilities. The flexibility of the hemicerebellectomized and control animals in learning a four-choice learning task, adapting to ever-changing response rules was investigated. While in the initial phase of the task both experimental groups exhibited similar performances, only the control animals significantly improved their performance as the sessions went by. The lack of improvement in lesioned animals' performance rendered their responses particularly defective in the final phases of the task, when conversely intact animals performed best, exploiting their "learning to learn" ability. The findings demonstrate the defective influence of the cerebellar lesion on the acquisition, not the execution, of new responses. The results underline the crucial role of the cerebellum in mediating cognitive flexibility behaviors. (C) 2009 Elsevier Inc. All rights reserved.