Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria.
Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria.
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DOI：
10.1179/096805103225002746
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
A. Hise;Illona Gillette-Ferguson;E. Pearlman
中科院分区：
文献类型：
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作者：
A. Hise;Illona Gillette-Ferguson;E. Pearlman
寄生线虫盘尾丝虫感染与皮肤和角膜炎症有关，可导致失明。角膜损伤被认为是由于宿主对眼睛中退化的微丝虫的炎症反应而发生的。我们利用小鼠角膜炎症（角膜炎）模型来研究与河盲症相关的免疫和炎症反应。将O. volvulus的可溶性提取物注射到小鼠的角膜中，O. volvulus是一种含有内共生细菌Wolbachia或Acanthocheilonema viteae（一种不会自然感染细菌的线虫）的丝虫物种。观察炎症反应和角膜变化。我们证明了内共生沃尔巴克氏菌和toll样受体4 （TLR4）在眼盘尾丝虫病发病机制中的主要作用。
Infection with the parasitic nematode Onchocerca volvulus is associated with inflammation of the skin and cornea that can lead to blindness. Corneal damage is thought to occur as a result of the host inflammatory responses to degenerating microfilariae in the eye. We have utilized a murine model of corneal inflammation (keratitis) to investigate the immune and inflammatory responses associated with river blindness. Soluble extracts of O. volvulus, a filarial species that contains the endosymbiont bacteria Wolbachia or Acanthocheilonema viteae (a nematode not naturally infected with the bacteria) were injected into mouse corneas. Inflammatory responses and corneal changes were measured. We demonstrated a major role for endosymbiont Wolbachia bacteria and Toll-like receptor 4 (TLR4) in the pathogenesis of ocular onchocerciasis.