Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy
Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy
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DOI：
10.1093/infdis/jix372
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发表时间：
2017-09-15
影响因子：
6.4
通讯作者：
Laufer, Miriam K.
中科院分区：
文献类型：
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作者：
Boudova, Sarah;Divala, Titus;Laufer, Miriam K.
与怀孕相关的恶性疟原虫感染会影响母亲和新生儿的健康，但人们对这些感染对婴儿疟疾易感性的影响知之甚少。我们对 473 对母婴在怀孕期间和 2 岁时进行了跟踪调查。我们观察到，与怀孕期间没有疟疾的母亲所生的孩子相比，患有胎盘疟疾的母亲所生的孩子在出生后第一年患疟疾的风险增加，但没有胎盘隔离证据的外周感染母亲所生的孩子则没有。胎盘隔离的疟疾感染对婴儿对疟疾感染的易感性具有长期影响。
Pregnancy-associated Plasmodium falciparum infection impacts the health of mothers and newborns, but little is known about the effects of these infections on infant susceptibility to malaria. We followed 473 mother-infant pairs during pregnancy and through 2 years of age. We observed that children born to mothers with placental malaria, but not those born to mothers with peripheral infection without evidence of placental sequestration, had increased risk of malaria during the first year of life compared with children born to mothers with no malaria during pregnancy. Malaria infections with placental sequestration have long-lasting impact on infant susceptibility to malaria infection.