Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity
Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity
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DOI：
10.1016/j.cub.2021.10.020
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发表时间：
2021-12-20
期刊：
影响因子：
9.2
通讯作者：
Axel, Richard
中科院分区：
文献类型：
--
作者：
Devineni, Anita, V;Deere, Julia U.;Axel, Richard
The brain generates internal representations that translate sensory stimuli into appropriate behavior. In the taste system, different tastes activate distinct populations of sensory neurons.我们研究了果蝇味觉反应的时间特性，发现不同类型的味觉感觉神经元在其反应动力学方面表现出显着差异。在唇瓣中的苦味感觉神经元中观察到对刺激开始（ON 响应）和偏移（OFF 响应）的强烈反应，而腿部和其他类型的唇部味觉神经元中的苦味神经元仅表现出 ON 响应。单个标签苦味神经元通过需要经典苦味受体的细胞内在机制产生“开”和“关”反应。 A single receptor complex likely generates both ON and OFF responses to a given bitter ligand.外周的这些开和关反应被传播到介导厌恶学习的多巴胺能神经元，当苦味被用作强化线索时，关反应的存在会影响突触可塑性。 These studies reveal previously unknown features of taste responses that impact neural circuit function and may be important for behavior.此外，这些研究表明，关闭反应可以极大地影响基于时间的突触可塑性，这被认为是联想学习的基础。
The brain generates internal representations that translate sensory stimuli into appropriate behavior. In the taste system, different tastes activate distinct populations of sensory neurons. We investigated the temporal properties of taste responses in Drosophila and discovered that different types of taste sensory neurons show striking differences in their response dynamics. Strong responses to stimulus onset (ON responses) and offset (OFF responses) were observed in bitter-sensing neurons in the labellum, whereas bitter neurons in the leg and other classes of labellar taste neurons showed only an ON response. Individual labellar bitter neurons generate both ON and OFF responses through a cell-intrinsic mechanism that requires canonical bitter receptors. A single receptor complex likely generates both ON and OFF responses to a given bitter ligand. These ON and OFF responses in the periphery are propagated to dopaminergic neurons that mediate aversive learning, and the presence of the OFF response impacts synaptic plasticity when bitter is used as a reinforcement cue. These studies reveal previously unknown features of taste responses that impact neural circuit function and may be important for behavior. Moreover, these studies show that OFF responses can dramatically influence timing-based synaptic plasticity, which is thought to underlie associative learning.