Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans
Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans
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DOI：
10.1007/s00535-012-0681-1
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发表时间：
2013-04-01
影响因子：
6.3
通讯作者：
Shimosegawa, Tooru
中科院分区：
文献类型：
--
作者：
Kanno, Takeshi;Iijima, Kastunori;Shimosegawa, Tooru
由影响整个社会的事件所产生的社会压力。例如，在一个实施例中，自然灾害，提供了一个独特的，间接的方式来确定心理压力和人类消化性溃疡疾病之间的关系。本研究调查了2011年3月11日东日本大地震前后消化性溃疡发病率的变化规律。回顾性收集了2011年东日本大地震后3个月内位于地震灾区中部的7家主要医院的消化性溃疡患者的临床资料，并与上年同期（2010年）数据进行了比较。符合条件的受试者根据幽门螺杆菌感染状况和非甾体抗炎药（NSAIDs）摄入情况分为四组，地震后各类型消化性溃疡的发病率增加了1.5倍，尤其是出血性溃疡的发病率增加了2.2倍;出血性溃疡中胃溃疡/十二指肠溃疡的比例也显著增加（P < 0.05）。在消化性溃疡的病因中，非H。幽门螺杆菌和非NSAID溃疡显著增加，从2010年的13%增加到2011年的24%（p < 0.05）。除了消化性溃疡的发病率增加外，还观察到东日本大地震后疾病的组成变化。非H. pylori和非NSAID溃疡的发生表明，心理应激单独诱导人类消化性溃疡，与H.幽门螺杆菌感染和NSAID摄入。
Societal stress derived from an event that affects the whole society, e. g., a natural disaster, provides a unique, indirect way of determining the relationship between psychological stress and peptic ulcer disease in humans. In this study, we investigated the changing patterns of the incidence of peptic ulcers before and after the Great East Japan earthquake, which occurred on 11 March, 2011.Clinical data of patients with peptic ulcers were retrospectively collected during the 3 months after the earthquake (2011) from 7 major hospitals in the middle of the stricken area, and were compared with the data for the same period of the previous year (2010). The eligible subjects were classified into four groups according to Helicobacter pylori infection status and intake of nonsteroidal anti-inflammatory drugs (NSAIDs).The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake, and in particular, the incidence of hemorrhagic ulcers was 2.2-fold increased; the gastric ulcer/duodenal ulcer ratio in hemorrhagic ulcers was also significantly increased (p < 0.05). Regarding the etiology of the peptic ulcers, the proportion of non-H. pylori and non-NSAID ulcers was significantly increased, from 13 % in 2010 to 24 % in 2011 after the earthquake (p < 0.05).In addition to the increased incidence of peptic ulcers, compositional changes in the disease were observed after the Great East Japan earthquake. The significant increase in the proportion of non-H. pylori and non-NSAID ulcers after the earthquake indicated that psychological stress alone induced peptic ulcers in humans independently of H. pylori infection and NSAID intake.