Conjunctive reward–place coding properties of dorsal distal CA1 hippocampus cells
Conjunctive reward–place coding properties of dorsal distal CA1 hippocampus cells
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DOI：
10.1007/s00422-020-00830-0
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发表时间：
2020-04
影响因子：
1.9
通讯作者：
Zhuocheng Xiao;Kevin K. Lin;J. Fellous
中科院分区：
文献类型：
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作者：
Zhuocheng Xiao;Kevin K. Lin;J. Fellous
动物或机器人的自主空间导航需要空间位置和值之间的关联。海马位置细胞参与目标导向的空间导航和空间记忆的巩固。最近，Gauthier和Tank（Neuron 99（1）：179-193，2018. https：//doi.org/10.1016/j.neuron.2018.06.008）已经确定了一个与奖励目标相关的海马细胞亚群。然而，这些细胞的尖峰活动和目标表征之间的关系仍然难以捉摸。我们分析了实验中的数据，在这些实验中，大鼠经历了五个连续的任务，其中奖励位置和空间背景被操纵。我们发现CA 1群体的属性不断从位置细胞奖励细胞。具体来说，我们发现典型的位置细胞不敏感的奖励位置，奖励细胞，只在正确的奖励馈线发射在每个任务中，无论上下文，和“混合细胞”的空间位置和奖励位置的变化作出反应。奖励细胞主要对奖励的传递做出反应，而不是对它的期望做出反应。此外，我们发现一小群神经元在5任务会话中在位置和奖励细胞属性之间转换。我们的结论是，一些锥体细胞（如果不是全部）整合空间和奖励输入到不同程度。这些结果提供了深入了解CA 1锥体细胞的整合编码特性，重点是它们以混合和可塑的方式携带空间和奖励信息的能力。这种合取编码属性提示重新思考当前的空间导航计算模型，其中海马空间和皮层下的值表示是独立的。
Autonomous motivated spatial navigation in animals or robots requires the association between spatial location and value. Hippocampal place cells are involved in goal-directed spatial navigation and the consolidation of spatial memories. Recently, Gauthier and Tank (Neuron 99(1):179–193, 2018. https://doi.org/10.1016/j.neuron.2018.06.008) have identified a subpopulation of hippocampal cells selectively activated in relation to rewarded goals. However, the relationship between these cells’ spiking activity and goal representation remains elusive. We analyzed data from experiments in which rats underwent five consecutive tasks in which reward locations and spatial context were manipulated. We found CA1 populations with properties continuously ranging from place cells to reward cells. Specifically, we found typical place cells insensitive to reward locations, reward cells that only fired at correct rewarded feeders in each task regardless of context, and “hybrid cells” that responded to spatial locations and change of reward locations. Reward cells responded mostly to the reward delivery rather than to its expectation. In addition, we found a small group of neurons that transitioned between place and reward cells properties within the 5-task session. We conclude that some pyramidal cells (if not all) integrate both spatial and reward inputs to various degrees. These results provide insights into the integrative coding properties of CA1 pyramidal cells, focusing on their abilities to carry both spatial and reward information in a mixed and plastic manner. This conjunctive coding property prompts a re-thinking of current computational models of spatial navigation in which hippocampal spatial and subcortical value representations are independent.