CHROMOSOME INSTABILITY IS ASSOCIATED WITH HYPODIPLOID CLONES IN MYELODYSPLASTIC SYNDROMES
CHROMOSOME INSTABILITY IS ASSOCIATED WITH HYPODIPLOID CLONES IN MYELODYSPLASTIC SYNDROMES
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DOI：
10.1111/j.1601-5223.1984.tb00444.x
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发表时间：
1984-01-01
期刊：
影响因子：
2.7
通讯作者：
BORGSTROM, GH
中科院分区：
文献类型：
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作者：
KNUUTILA, S;TEERENHOVI, L;BORGSTROM, GH
对30例骨髓增生异常综合征或白血病前期综合征患者进行了染色体研究。14名患者的染色体不稳定性细胞数量增加，例如，非克隆性染色体畸变。不稳定组患者的克隆性染色体畸变（14例患者中有12例）多于非不稳定组患者（16例患者中有7例）。在不稳定组中，5例患者具有亚二倍体克隆，8例患者具有7号染色体畸变的克隆，而在非不稳定组中未观察到这些畸变。染色体不稳定性与亚二倍体克隆和/或7号染色体畸变密切相关。染色体不稳定性与既往化疗和/或放疗相关（7例未接受治疗的患者中仅1例属于非不稳定组）。不稳定组中有一半的患者以前没有接受过化疗或放疗。本文还讨论了这些患者染色体不稳定的原因。
Chromosome study on 30 patients with a myelodysplastic or preleukemic syndrome was performed. Fourteen patients had an increased number of cells with chromosome instability, e.g., non-clonal chromosome aberrations. The patients in the instability group had more clonal chromosome aberrations (12 out of 14 patients) than did patients in the non-instability group (7 out of 16 patients). In the instability group 5 patients had a hypodiploid clone and 8 patients had a clone with an aberration in chromosome 7, whereas these aberrations were not seen in the non-instability group. Chromosome instability associates strongly with hypodiploid clones and/or with aberrations in chromosome 7. Chromosome instability associates with previous chemotherapy and/or radiation therapy (only 1 out of 7 patients with non-therapy belonged to the non-instability group). Half of the patients in the instability groups had no previous chemo- or radiation therapy. The causes of chromosome instability in these patients are discussed.