Serum Concentration and Skin Expression of S100A7 (Psoriasin) in Patients Suffering from Hidradenitis Suppurativa
Serum Concentration and Skin Expression of S100A7 (Psoriasin) in Patients Suffering from Hidradenitis Suppurativa
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DOI：
10.1159/000510689
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发表时间：
2020-11-17
期刊：
影响因子：
3.4
通讯作者：
Szepietowski, Jacek Cezary
中科院分区：
文献类型：
--
作者：
Batycka-Baran, Aleksandra;Baran, Wojciech;Szepietowski, Jacek Cezary
背景：化脓性汗腺炎（HS）是一种慢性炎症性皮肤病。先天性免疫失调在HS发病机制中的重要作用已被强调。S100 A7（银屑病）是一种先天性抗菌蛋白，发挥促炎和趋化作用。目的：本研究的目的是研究与健康对照相比，HS个体中S100 A7的血清浓度。此外，我们评估了S100 A7在病变HS皮肤中的表达，并与病变周围（临床上未受累）HS皮肤和正常皮肤进行了比较。方法：采用ELISA试剂盒检测血清S100 A7浓度。使用qRT-PCR和免疫荧光染色评估皮肤中S100 A7的表达。结果：我们发现S100 A7在病变HS皮肤中的表达增加，与病变周围HS皮肤相比（p = 0.0017）。S100 A7在HS皮损中的表达与血清C-反应蛋白浓度和根据Hurley分期的疾病严重程度呈正相关。与健康对照组和银屑病患者相比，HS患者的S100 A7血清浓度降低。结论：S100 A7在HS皮损中表达上调，可能参与了HS的发病过程。
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action. Objectives: The objective of the study was to investigate serum concentrations of S100A7 in individuals with HS as compared to healthy controls. Further, we evaluated the expression of S100A7 in lesional HS skin as compared to perilesional (clinically uninvolved) HS skin and normal skin. Methods: Serum concentrations of S100A7 were evaluated with a commercially available ELISA kit. The expression of S100A7 in the skin was assessed using qRT-PCR and immunofluorescence staining. Results: We found increased expression of S100A7 in lesional HS skin as compared to perilesional HS skin (p = 0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and the severity of disease according to Hurley staging. The serum concentration of S100A7 in individuals with HS was decreased as compared to healthy controls and patients with psoriasis. Conclusions: Upregulated in lesional HS skin, S100A7 may enhance the inflammatory process and contribute to the HS pathogenesis.