The Relationship Between Asthma and Bronchiolitis is Modified by TLR4, CD14, and IL-13 Polymorphisms
The Relationship Between Asthma and Bronchiolitis is Modified by TLR4, CD14, and IL-13 Polymorphisms
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DOI：
10.1002/ppul.22978
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Hong, Soo-Jong
中科院分区：
文献类型：
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作者：
Jung, Young-Ho;Seo, Ju-Hee;Hong, Soo-Jong
背景哮喘是一种复杂的遗传性疾病，与遗传和环境因素有关。本研究旨在探讨Toll样受体4(TLR4)、分化簇14(CD14)和白介素13(IL-13)基因多态性与毛细支气管炎(毛细支气管炎)在儿童哮喘发病中的联合作用。结果TLR4(Rs1927911)、CD14(Rs2569190)和IL-13(Rs20541)基因多态性分别是影响儿童哮喘诊断的独立危险因素，在学龄儿童中，父母有哮喘史(调整后的优势比[AOR]2.56[95%CI 1.16~5.63]，AOR 3.60[95%CI 1.66~7.76])和毛细支气管炎史(AOR 3.11[95%CI 1.84~5.24]、AOR 3.94[95%CI 2.27~6.84])是哮喘诊断的独立危险因素。与TLR4基因各CC、CD14基因TT、IL13基因GG且无毛细支气管炎病史的儿童相比，有TLR4基因CT或TT基因多态和既往毛细支气管炎史的儿童发生哮喘的风险分别高4.23倍和5.34倍，具有CD14基因TT和毛细支气管炎既往病史的儿童发生哮喘的风险分别高3.57倍和7.22倍；有IL-13基因多态的GA或AA和既往毛细支气管炎史的儿童患哮喘的风险分别是有毛细支气管炎史的3.21倍和4.13倍。结论哮喘或过敏性鼻炎家族史和毛细支气管炎史是儿童哮喘发生的独立危险因素。朝鲜族儿童TLR4、CD14和IL-13基因多态性改变了哮喘和毛细支气管炎之间的关系。儿科肺单醇。2015年；50：8-16。(C)2013年威利期刊公司。
BackgroundAsthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.MethodsA modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.ResultsIn elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI 1.16-5.63], aOR 3.60 [95% CI 1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI 1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent risk factors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13 polymorphism and no past history of bronchiolitis, children with CT or TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.ConclusionsFamily history of asthma or allergic rhinitis and past history of bronchiolitis could be independent risk factors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children. Pediatr Pulmonol. 2015; 50:8-16. (c) 2013 Wiley Periodicals, Inc.