Recent advances of long noncoding RNAs involved in the development of multiple sclerosis
Recent advances of long noncoding RNAs involved in the development of multiple sclerosis
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长非编码RNA参与多发性硬化症发展的最新进展
DOI：
10.1016/s1875-5364(20)30003-0
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发表时间：
2020-01-01
影响因子：
4.6
通讯作者：
Guo Wei
中科院分区：
文献类型：
--
作者：
Li Qian-Wen;Lei Wen;Guo Wei
鉴于自身免疫性疾病患者的迅速增加和缺乏令人满意的治疗方法，发现新的有效的治疗靶点已成为当务之急。最近的研究表明，长非编码RNA(Long Non Coding RNAs，LncRNAs)在多发性硬化症(MS)的发生发展中起着至关重要的作用，这为揭示与多发性硬化症进展相关的新机制提供了新的机会。此外，还讨论了作为治疗靶点和诊断标记物的lncRNAs的潜在临床相关性。
Given the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies, the discovery of novel and effective therapeutic targets have been in an urgent demand. Recent studies have revealed that long noncoding RNAs (lncRNAs) play crucial roles in the development of multiple sclerosis (MS), which provides a new opportunity of uncovering novel mechanism associated with the progression of MS. This review highlights the dysregulation of lncRNAs in the development of MS in patients and animal models. Additionally, the potential clinical relevance of lncRNAs severed as therapeutic targets and diagnostic markers are discussed.