Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies
Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies
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DOI：
10.1016/j.mito.2017.08.014
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发表时间：
2017-09-01
期刊：
影响因子：
4.4
通讯作者：
Di Polo, Adriana
中科院分区：
文献类型：
--
作者：
Ito, Yoko A.;Di Polo, Adriana
视网膜神经节细胞是在青光眼和其他视神经病变中选择性死亡的神经元，具有极其活跃的新陈代谢，并且特别容易受到线粒体功能障碍的影响。线粒体是一种极其动态的细胞器，不断响应内源性和环境信号，轻松满足神经元网络的能量需求。线粒体生物发生、融合、裂变、运输和降解的高度协调调节对于维持 RGC 树突和轴突末端的能源昂贵突触以实现最佳神经传递至关重要。本综述重点关注迄今为止在了解线粒体动力学和质量控制的生物学方面取得的进展，以及这些过程的失调如何深刻影响视神经疾病中视网膜神经节细胞的活力和功能。
Retinal ganglion cells, the neurons that selectively die in glaucoma and other optic neuropathies, are endowed with an exceedingly active metabolism and display a particular vulnerability to mitochondrial dysfunction. Mitochondria are exquisitely dynamic organelles that are continually responding to endogenous and environmental cues to readily meet the energy demand of neuronal networks. The highly orchestrated regulation of mitochondrial biogenesis, fusion, fission, transport and degradation is paramount for the maintenance of energy expensive synapses at RGC dendrites and axon terminals geared for optimal neurotransmission. The present review focuses on the progress made to date on understanding the biology of mitochondrial dynamics and quality control and how dysregulation of these processes can profoundly affect retinal ganglion cell viability and function in optic nerve diseases.