Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.
Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line.
复制标题
Interleukin-1beta 通过增加供应独立线的斜率来改变兔子的氧气输送-氧气消耗关系。
DOI：
10.1097/00024382-200014020-00020
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发表时间：
2000
期刊：
影响因子：
3.1
通讯作者：
H. Sugimoto
中科院分区：
文献类型：
--
作者：
Y. Kuwagata;J. Oda;S. Matsuyama;M. Nishino;N. Hashiguchi;H. Ogura;H. Tanaka;H. Sugimoto
当系统氧输送（DO2）降低时，氧消耗（VO2）维持到达到临界水平（DO2crit）。脓毒症被认为使DO2crit向右移动，并延长了依赖供应的部分。我们检测了与脓毒症相关的关键细胞因子之一白细胞介素(IL)-1 β对DO2-VO2关系的影响。15只兔接受逐步心脏填塞，通过将一个手工气球充气放置在心包囊内，将DO2降低到10%。在分级心包填塞前，7只兔静脉注射10微克/千克il -1 β （il -1 β组）。其余患者单独给予生理盐水治疗（对照组）。用双线法分析了DO2-VO2的关系。il -1 β显著降低平均动脉压（65 +/- 11 mmHg，基线85 +/- 7 mmHg），但不改变心输出量。与对照组相比，il -1 β组显示出明显更陡峭的非供给线斜率（分别为0.19 +/- 0.02和0.11 +/- 0.02），这导致DO2crit向左移动（il -1 β组，8.7 +/- 1.7 ml/kg x min与对照组相比，11.7 +/- 0.7 ml/kg x min）。il -1 β组门静脉的PO2和血浆乳酸水平也高于对照组。这些结果表明，甚至在VO2成为供应依赖之前，il -1 β就会损害全身氧摄取，可能是由于包括内脏循环在内的血流分布不均。
When systemic oxygen delivery (DO2) is reduced, oxygen consumption (VO2) is maintained until a critical level is reached (DO2crit). Sepsis is thought to shift DO2crit to the right and lengthen the supply-dependent portion. We tested the effect of interleukin (IL)-1beta, which is one of the key cytokines related to sepsis, on the DO2-VO2 relationship. Fifteen rabbits were subjected to stepwise cardiac tamponade to reduce DO2 to 10% by inflating a handmade balloon placed into the pericardial sac. Seven rabbits were given 10 microg/kg of IL-1beta intravenously (IL-1beta group) prior to the graded cardiac tamponade. The remainder received saline alone (control group). The DO2-VO2 relationship was analyzed by the dual-line method. IL-1beta significantly decreased mean arterial pressure (65 +/- 11 mmHg from baseline 85 +/- 7 mmHg) without altering cardiac output. The IL-1beta group showed significantly steeper supply-independent line slopes than did the control group (0.19 +/- 0.02 vs. 0.11 +/- 0.02, respectively), which resulted in a DO2crit shift to the left (IL-1beta group, 8.7 +/- 1.7 ml/kg x min vs. control, 11.7 +/- 0.7 ml/kg x min). The IL-1beta group also showed greater PO2 and plasma lactate levels in the portal vein than did the control group. These results indicate that IL-1beta impairs systemic oxygen uptake even before VO2 becomes supply-dependent, presumably due to maldistribution of the blood flow including the splanchnic circulation.