Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.
Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.
复制标题
DOI：
10.3109/13550284.2010.504248
复制
发表时间：
2010-10
影响因子：
3.2
通讯作者：
Everall IP
中科院分区：
文献类型：
--
作者：
Tatro ET;Nguyen TB;Bousman CA;Masliah E;Grant I;Atkinson JH;Everall IP
重度抑郁症（MDD）是人类免疫缺陷病毒（HIV）感染者发病的重要原因。FKBP5是一个具有单核苷酸多态性（SNP）rs1360780和rs3800373的与MDD相关的候选基因。该基因产物及其相对物FKBP4与糖皮质激素受体物理相关，糖皮质激素受体的功能与MDD病理生理学有关。由于这些基因在血液和大脑中表达，并在HIV感染中升高，我们探讨了基因表达，基因型和MDD症状之间的关系。作为CNS HIV抗逆转录病毒作用研究的一部分，对诊断为MDD并献血用于基因分型和基因表达分析的受试者（N = 57）进行了纵向随访评估。受试者在符合和不符合MDD发作标准的相邻访视时献血。临床参数的变化与基因表达的变化进行比较。FKBP5表达的变化与Beck抑郁量表（BDI）的变化相关，在rs3800373的GG基因型（P = .013）和rs1360780的TT携带者（P = .02）中进行MDD →正常胸腺比较。在正常胸腺→ MDD比较中，GG纯合子、FKBP5表达与BDI更严重的变化相关。FKBP4表达的变化与临床或抑郁测量的变化无关。对于rs3800373的GG携带者，较高的FKBP5表达与较大的症状变化相关。
Major depressive disorder (MDD) is a significant cause of morbidity in people living with the human immunodeficiency virus (HIV). FKBP5 is a candidate gene with single-nucleotide polymorphisms (SNPs) rs1360780 and rs3800373 associated with MDD. This gene product and its relative, FKBP4, physically associate with the glucocorticoid receptor whose function is implicated in MDD pathophysiology. Because these genes are expressed in blood and brain and elevated in HIV infection, we explored the relationship between gene expression, genotype, and MDD symptoms. Longitudinally followed subjects (N = 57) as part of the CNS HIV AntiRetroviral Effects Research study, with diagnosed MDD and who donated blood for genotyping and gene expression analysis, were assessed. Subjects donated blood on adjacent visits with and without meeting criteria for MDD episode. Changes in clinical parameters were compared changes in gene expression. Change in FKBP5 expression correlated with change in Beck Depression Inventory (BDI) for MDD → euthymic comparison in GG genotype of rs3800373 (P = .013) and TT carriers of rs1360780 (P = .02). In euthymic → MDD comparison, GG homozygous, FKBP5 expression correlated with more severe change in BDI. Change in FKBP4 expression did not correlate with changes in clinical or depression measurements. Higher FKBP5 expression correlated with greater symptom change for GG carriers of rs3800373.
登录
查看更多内容
影响因子：
2.1
作者：
Kirchheiner, Julia;Lorrh, Rainer;Brockmdller, Juergen
通讯作者：
Brockmdller, Juergen
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
3.7
作者：
Binder, E. B.;Kuenzel, H. E.;Holsboer, F.
通讯作者：
Holsboer, F.
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B
影响因子：
2.9
作者：
Tatro ET;Everall IP;Kaul M;Achim CL
通讯作者：
Achim CL